The literature review reveal that [1,4]-oxazine derivatives represent one of the most active classes of compounds possessing wide spectrum of biodynamic activities and use as potent therapeutic agents. In the present work, a series of Schiff base of 2-(2,3-dihydro-2-oxonaphtho[2,1-b][1,4]oxazin-1-yl)acetohydrazide, 5a-5j has been synthesized using 1-aminonaphthalen-2-ol. Various aromatic aldehyde were react with carbohydrazide 4 in the presence of acid to produce the 2-oxonaphtho[2,1-b][1,4]oxazin Schiff base derivatives with good yields. All synthesized compounds were characterized by IR, NMR and Mass spectrometry analysis.
The literature review reveal that [1,4]-oxazine derivatives represent one of the most active classes of compounds possessing wide spectrum of biodynamic activities and use as potent therapeutic agents. In the present work, a series of Schiff base of 2-(2,3-dihydro-2-oxonaphtho[2,1-b][1,4]oxazin-1-yl)acetohydrazide, 5a-5j has been synthesized using 1-aminonaphthalen-2-ol. Various aromatic aldehyde were react with carbohydrazide 4 in the presence of acid to produce the 2-oxonaphtho[2,1-b][1,4]oxazin Schiff base derivatives with good yields. All synthesized compounds were characterized by IR, NMR and Mass spectrometry analysis.
Bei der selektiven Demethylierung des Xanthonns (IIIa) ‐ dargestellt durch Kondensation der Benzoesäure (I) mit dem Phloroglucindiether (II) ‐ tritt: auch Debenzylierung ein unter Bildung des Dihydroxyxanthons (IIIb), das selektiv zu Laxanthon‐III (IIIc) acetyliert wird; die durchgeführte Synthese bestätigt die früher für Laxanthon‐III (aus Lawsonia inermis) ermittelte Struktur (IIIc).
Für den aus Prosopis spicigera isolierten Stoff Prosogerin‐Awurde die Struktur (VIa) ermittelt; diese Struktur wird jetzt durch die Totalsynthese des Flavons bestätigt: Acylierung des o‐Hydroxy‐acetophenons (Ia) mit Piperonylchlorid (II) ergibt den Ester (IIIa), der nach Baker‐Venkataraman zu dem Derivat (IVa) isomerisiert wird.
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