Introduction: End stage renal disease (ESRD) patients undergoing hemodialysis (HD) have higher incidence of diabetic retinopathy (DR) and diabetic macular edema. Optical coherence tomography (OCT) which both diagnoses and quantifies degree of macular edema is gold standard for evaluating macular thickness. Materials and methods: We studied 30 patients, with DR who were treated with hemodialysis for ESRD. All patients underwent OCT examination 30 minutes before and after a hemodialysis session. Blood pressure (BP), weight, serum osmolality, glycemic hemoglobin and albumin levels were measured before and after hemodialysis. Student’s t-test and linear regression analysis test were used to analyze data. SPSS version 21.0 system was used for all statistical analyses and p value <0.05 was accepted as statistically significant. Results: In our study, BCVA failed to change significantly after the HD. Central and average macular thickness decreased by 3.49% and 1.61% respectively, both were statistically significant. Changes in maximum, central and average macular thickness, as well as in total macular volume were found to be significantly affected by changes in serum osmolality (p=0.04, 0.002, 0.02 and 0.03, respectively).We found no significant changes in maximum/average macular thickness with changes in total body weight or in mean arterial pressure after HD. Conclusion: Hemodialysis significantly decreases maximum macular thickness assessed by OCT in chronic renal failure diabetic patients with macular edema with no change in BCVA. Osmolality changes after hemodialysis were significantly associated with macular thickness.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.