Dechlorane Plus (DP) is a proposed
alternative to the legacy flame
retardant decabromodiphenyl ether (BDE-209), a major component of
Deca-BDE formulations. In contrast to BDE-209, toxicity data for DP
are scarce and often focused on mice. Validated dietary in vivo exposure
of the marine bivalve (Mytilus galloprovincialis) to both flame retardants did not induce effects at the physiological
level (algal clearance rate), but induced DNA damage, as determined
by the comet assay, at all concentrations tested. Micronuclei formation
was induced by both DP and BDE-209 at the highest exposure concentrations
(100 and 200 μg/L, respectively, at 18% above controls). DP
caused effects similar to those by BDE-209 but at lower exposure concentrations
(5.6, 56, and 100 μg/L for DP and 56, 100, and 200 μg/L
for BDE-209). Moreover, bioaccumulation of DP was shown to be concentration
dependent, in contrast to BDE-209. The results described suggest that
DP poses a greater genotoxic potential than BDE-209.
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