As a result of the study of 9 anuric patients, I believe that death from anuria usually is due to the disorganization of the structure of the internal environment and not to the accumulation of urea or hypothetic toxins. Therefore the rational approach is to preserve the normal volume and composition of the body fluids.In the presence of anuria and in the absence of intake of food and fluids, the volume of body water will be progressively reduced through insensible expenditure by way of the lungs and the skin, and the concen¬ trations of body fluid electrolytes will rise unless, as is occasionally the case, losses occur in vomitus and in diarrheal stools. Owing to consump¬ tion of body protein, the quantity of the products of the oxidation of pro¬ tein in the body fluids will be increased and their concentrations will, therefore, rise more extensively than those of the electrolytes. It is also evident that an intake of protein will add to the accumulation of nitrog¬ enous end products. On the other hand, if one provides a water intake which is larger than the insensible expenditure, the concentrations of the electrolytes will fall below their physiologic values.
THIAMINE DEFICIENCY I N DIABETIC RATSin tolerance between various species of animals and also among the individuals of the same species. The observation that single blood transfusions in dogs in a state of extreme depression of the protlironibin level were of only temporary benefit, is paralleled by similar clinical findings"9 and calls for particular care in avoiding excessively high dosage.Certain workers1' ' 9 have claimed amelioration of human diabetes with the use of tliianiine, particularly when given in combination with other vitamins. RIartid reported intensification of diabetes in depancreatized dogs on a vitamin B-free diet, with remarkable improvement in carboh]idrate tolerance when thiamine and flavin were given. On the other haiid, in normal rats, Lepkovsky, Wood and Evans5 found the glucose tolerance impaired only in the later .stages of deficiency and McIntyre and Burke' noted very little change in glucose tolerance, either with deficiency or excess of vitamin B.The present study was undertaken to determine the effect of deprivation of thiamine on the diabetic condition of depancreatized rats and to ascertain whether or not diabetic animals, when deprived of thiamine, develop signs of deficiency more readily than those without diabetes. It was hoped that the results obtained might elucidate thepossible r6le of vitamin C, and specifically of thiamine, in the peripheral neuritis encountered in patients with severe, uncontrolled d i a b e t e~.~ 1 Vorhaus, hf.
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