A dynamic tension has developed in prevention science regarding two imperatives: (a) fidelity of implementation-the delivery of a manualized prevention intervention program as prescribed by the program developer, and (b) program adaptation-the modification of program content to accommodate the needs of a specific consumer group. This paper examines this complex programmatic issue from a community-based participatory research approach for program adaptation that emphasizes motivating community participation to enhance program outcomes. Several issues, key concepts, and implementation strategies are presented under a strategic approach to address issues of fidelity and adaptation. Despite the noted tension between fidelity and adaptation, both are essential elements of prevention intervention program design and they are best addressed by a planned, organized, and systematic approach. Towards this aim, an innovative program design strategy is to develop hybrid prevention programs that "build in" adaptation to enhance program fit while also maximizing fidelity of implementation and program effectiveness.

This study examined links between parent-youth differential acculturation and youth substance-use likelihood in a sample of 73 recently immigrated Latino families with middle-school-aged youth. Multiple agents were utilized to assess family functioning and youth outcomes. Findings suggested that a greater level of differential acculturation between parents and youth was associated with greater likelihood of future youth substance use. However, the relationship between differential acculturation and youth substance use was mediated by family stress processes and effective parenting practices. Differential acculturation was related to increases in family stress and decreases in effective parenting practices, and each of these, in turn, was related to increases in future substance-use likelihood among Latino youth. Findings implicate the need for advancing policies and practices that address acculturation as a family process, rather than as merely an individual psychological phenomenon.

A randomized experimental test of the implementation feasibility and the efficacy of a culturally adapted Parent Management Training intervention was conducted with a sample of 73 Spanish-speaking Latino parents with middle-school-aged youth at risk for problem behaviors. Intervention feasibility was evaluated through weekly parent satisfaction ratings, intervention participation and attendance, and overall program satisfaction. Intervention effects were evaluated by examining changes in parenting and youth adjustment for the intervention and control groups between baseline and intervention termination approximately 5 months later. Findings provided strong evidence for the feasibility of delivering the intervention in a larger community context. The intervention produced benefits in both parenting outcomes (i.e., general parenting, skill encouragement, overall effective parenting) and youth outcomes (i.e., aggression, externalizing, likelihood of smoking and use of alcohol, marijuana, and other drugs). Differential effects of the intervention were based on youth nativity status.

This study tested a culturally informed model of academic well-being for 278 Latino youth. We examined detrimental effects of discriminatory experiences and protective effects of social support on self-reported academic outcomes. Models specified main and buffering effects of social support and compared contributions of support provided by parents, school, and peers. Data indicated that discrimination was associated with lower academic well-being, social support buffered effects of discrimination on academic well-being, and parental support was most predictive of greater academic well-being. Combined sources of social support were more important than any one source alone. Implications for culturally specified research, preventive interventions, and practitioners are discussed.

This article describes results from the Oregon Latino Youth Survey, which was designed to identify factors that promoted or hindered academic success for Latino middle- and high-school youngsters. The study samples included a total of 564 Latino and non-Latino students and parents. Analyses showed that Latino students reported a high frequency of discriminatory experiences and institutional barriers at school, and that they and their parents were more likely to experience institutional barriers compared to non-Latinos. Further, Latino students and parents reported that they/their youngsters were more likely to dropout of school compared to non-Latinos. Path models showed lower acculturation and more institutional barriers were related to less academic success for Latino students. More parent academic encouragement and staff extracurricular encouragement were associated with better academic outcomes for Latino students. Finally, family socioeconomic disadvantage had an indirect effect on Latino youngster academic success, through effects on parent monitoring and school involvement.

Significance Bacteria use regulatory modules called two-component systems to respond to changes in their surrounding environment. Bacteria have evolved ways to insulate each two-component system, thereby preventing unwanted cross-talk. Here we describe an example where partners of distinct two-component systems show remarkable cross-specificity for each other. Loss of the quorum-sensing Escherichia coli (Qse)BC sensor QseC leads to robust cross-interaction of its cognate partner QseB with the polymyxin resistance (Pmr)AB two-component system. This cross-interaction in the absence of the cognate sensor is detrimental, severely attenuating pathogen virulence. Our findings suggest that ( i ) robust cross-talk between noncognate partners is possible and ( ii ) this interaction can be manipulated for developing antivirulence strategies against uropathogenic E. coli and potentially other QseBC−PmrAB-bearing pathogens.

This study provided a randomized, experimental test of the efficacy of a parent training intervention on coercive discipline, positive parenting practices, and child noncompliance in a sample of 238 divorcing mothers and their sons in Grades 1-3. Intervention effects were evaluated 5 times from baseline to 30 months. The intervention produced enduring benefits to coercive discipline, positive parenting, and boys' noncompliance. These benefits followed a classic prevention effect: Mothers and sons in the experimental group maintained stable outcome trajectories, whereas those in the control group deteriorated. The intervention's impact on boys' noncompliance was mediated independently by its impact on coercive discipline and positive parenting. Change in positive parenting was more strongly associated with change in noncompliance than was change in coercive discipline, although each explained unique variance in change in noncompliance.

This study examined behavioral and emotional adjustment in family contexts in which there was high versus low demand for adolescents to serve as language brokers in a sample of 73 recently immigrated Latino families with middle-school-aged adolescents. Language brokering was conceptualized as a family process rather than merely an individual phenomenon. Multiple agents were used to assess language brokering and parent and youth adjustment. Results indicated that high language brokering contexts had negative associations with family stress, parenting effectiveness, and adolescent adjustment in terms of academic functioning, socioemotional health, and substance use. The findings are particularly important given the limited and mixed findings from formative research on language brokering, particularly in areas within the United States with emerging immigrant populations. Findings suggest the need for advancing practices that increase language and cultural supports for immigrant families and support parents' efforts to foster positive youth and family adjustment.