We examined peer-reviewed studies in order to understand the current status of empirically-based evidence on the clinical applications of robots in the diagnosis and treatment of Autism Spectrum Disorders (ASD). Studies are organized into four broad categories: (a) the response of individuals with ASD to robots or robot-like behavior in comparison to human behavior, (b) the use of robots to elicit behaviors, (c) the use of robots to model, teach, and/or practice a skill, and (d) the use of robots to provide feedback on performance. A critical review of the literature revealed that most of the findings are exploratory and have methodological limitations that make it difficult to draw firm conclusions about the clinical utility of robots. Finally, we outline the research needed to determine the incremental validity of this technique.

The role of predrug cues in tolerance to ethanol-induced hypothermia was investigated in two experiments. The results of Experiment 1 demonstrated that tolerance was displayed only when the drug was administered in conjunction with environmental stimuli that had, in the past, accompanied ethanol administration. A conditional hyperthermic response was elicited when a placebo, instead of ethanol, was administered in conjunction with the usual ethanol cues. Results of Experiment 2 suggested that tolerance to ethanol-induced hypothermia can be extinguished by repeated placebo injections. These results indicate that associative processes, previously demonstrated to modulate opiate tolerance, also modulate ethanol tolerance.

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The effects of an alternative course of action on sustained escalation and persistence in the face of failure was investigated using a computerized stock investment task. Subjects invested in "stock" in two "markets" that yielded returns according to two-component multiple variable-interval schedules. Both markets yielded equal but intermittent return rates during the first phase. In the second phase, one market ceased to yield returns, while the return rate for the other market was unchanged. During the second phase, behavioral contrast effects were evident. Investing in the market that ceased to yield returns dropped precipitously, and investing in the unchanged market increased significantly. Although the behavior may be economically "irrational," it is predictable from the matching law and shows that interactions among a history of intermittent returns in a course of action, current return rate, and currently available alternative courses of action are important determinants of persisting in, or withdrawing from, a failing course of action.