SUMMARY Six patients with stones retained in the common bile duct after cholecystectomy and common duct exploration were treated by intraductal infusion of a sodium cholate solution. In the five patients whose stones were between the T-tube and the duodenum the treatment was successful within a few days. A stone became transiently impacted in the ampullary region soon after beginning therapy in three patients and produced mild pancreatitis in two. The only failure was in a patient whose stone was between the T-tube and the liver.
Although this toxicity is rare, clinicians should be aware of the potential for oxaprozin to cause hepatotoxicity and use caution when prescribing this medication. This case also stresses the importance of careful inquiry regarding drug or toxin exposure in cases of unexplained hepatitis.
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