Exploration of the effects of "minor" structural differences on the antitumor activity and toxicity of dimeric Catharanthus alkaloids resulted in the preparation of deacetylvinblastine amide (vindesine, VDS) from either vinblastine (VLB) or deacetylvinblastine. Adequate amounts of vindesine for biological testing were prepared by preferential hydrazinolysis of the C23-ester in the vindoline moiety of VLB, followed by hydrogenolysis of the resulting deacetylvinblastine hydrazide. Vindesine in its activity spectrum against rodent tumor systems resembles vincristine (VCR) rather than its parent VLB, while its neurotoxic potential appears to be less than that of VCR. The experimental models developed to estimate this potential include in vitro measurements of axoplasmic transport effects in the cat sciatic nerve and the estimation of neuromuscular disturbances in chickens and monkeys by vindesine in comparison with VCR. A radioimmunoassay for VLB, VCR, and VDS, developed by means of deacetylvinblastine acid azide, has been used to study the pharmacokinetics of vindesine in man. The clinical investigation of vindesine is in progress. Deacetylvinblastine, in contrast to earlier reports, showed activity against several murine tumor systems.

The first full annual inventory of West Virginia's forests reports 12.0 million acres of forest land or 78 percent of the State's land area. The area of forest land has changed little since 2000. Of this land, 7.2 million acres (60 percent) are held by family forest owners. The current growing-stock inventory is 25 billion cubic feet-12 percent more than in 2000-and averages 2,136 cubic feet per acre. Yellow-poplar continues to lead in volume followed by white and chestnut oaks. Since 2000, the saw log portion of growing-stock volume has increased by 23 percent to 88 billion board feet. In the latest inventory, net growth exceeded removals for all major species. Detailed information on forest inventory methods and data quality estimates is included in a DVD at the back of this report. Tables of population estimates and a glossary are also included. AcknowledgmentsThe authors would like to thank West Virginia's inventory crew members over the 2004-2008 inventory cycle:

Change in the health of sugar maple (Acersaccharum Marsh.) and associated northern hardwoods was evaluated for 3 years (1988–1990) in seven states and four provinces. Generally, levels of crown dieback and crown transparency (a measure of foliage density) in 165 stands decreased during this period. In 1990, less than 7% of all dominant–codominant sugar maples (n = 7317) exhibited crown dieback ≥ 20%. Significantly (p = 0.05) fewer of these maples were classified as having high crown transparency (≥ 30%) in 1990 compared with 1988. Crowns of maples that received moderate (31–60%) or heavy (> 60%) pear thrips (Taeniothripsinconsequens (Uzel)) damage for 1 year recovered the following year. Crowns of maples exposed to severe drought in 1988 (Wisconsin) continued to show the effects (high transparency) of this stress in 1990. A majority (69–71%) of the dominant–codominant sugar maples with high (≥ 20%) crown dieback had bole and (or) root damage. Of those maples with crown dieback ≥ 50%, 86% had bole and (or) root damage. The condition of sugar maple in operating sugar bushes and undisturbed stands was similar. The condition of sugar maple crowns was similar in locations presumably exposed to low, medium, and high levels of sulfate deposition.

A concise and scalable synthesis of LY231514 (1), a new pyrrolo[2,3-d]pyrimidine-based antitumor agent, is presented. Reaction of 2-bromo-4-arylbutanal 9 with 2,4-diamino-6-hydroxypyrimidine (10) regioselectively provided pyrrolo[2,3-d]pyrimidine 11, representing the core structure of the drug, in good yield. Assimilation of the glutamic acid residue by conventional means completed the synthesis. Development of the optimized synthetic route emphasized avoiding isolation of the relatively unstable aldehyde and bromoaldehyde intermediates.

The U.S. Forest Service Forest Inventory and Analysis (FIA) program collects sample plot data on all forest ownerships across the United States. FIA's primary objective is to determine the extent, condition, volume, growth, and use of trees on the Nation's forest land through a comprehensive inventory and analysis of the Nation's forest resources. The FIA program strives for transparency by making the methods and results of the inventory and analysis available to the public. The standard for distributing FIA data is the FIADatabase (FIADB). FIADB data for individual states can be downloaded from the FIA DataMart at https://www. fia.fs.fed.us/tools-data/. This report complements the Northern Research Station's FIA 5-year state reports and includes detailed information on forest inventory methods, important resource statistics, quality of estimates, and key references.

Studies of the displacement chemistry of 1,1-difluorocyclopropyldibenzosuberanyl alcohol 4 and its activated bromide derivative 6 have led to an improved approach to anti-2, a key precursor to LY335979 3HCl (1). Bromination of either syn-4 or anti-4 gave anti-oriented 6, indicating thermodynamically controlled product stereochemistry via a stabilized 1,1-difluorohomotropylium ion intermediate. Reaction of 6 with piperazine proceeded irreversibly to provide an isomeric mixture of piperazine products, with the syn:anti product ratio increased by solvent effects. Reaction of 6 with pyridine and pyrazine, on the other hand, gave anti-pyridinium and pyrazinium salts, respectively, apparently via equilibration of initially formed syn products. Reduction of pyrazinium salt 11 with lithium borohydride/TFA provided anti-2 unaccompanied by its syn isomer. A practical and expeditious approach to 1 was derived from these new results.

The second full, annualized inventory of Maine's forests was completed in 2008 after more than 3,160 forested plots were measured. Forest land occupies almost 17.7 million acres that represents 82 percent of the total land area of Maine. The dominant forest-type groups are maple/beech/yellow birch, spruce/fi r, white/red/jack pine, and aspen/white birch. Total statewide volume equals 25.5 billion ft 3 , resulting in almost 590 million ft 3 of live tree volume grown each year. The report also contains additional information on sustainability, biomass, carbon, forest health, land use change, and timber products. DVD included in this report includes detailed information on forest inventory methods and the quality of the estimates found in fi ve detailed tables (Tables A-E). A complete set of core tables are contained on the DVD or can be found online: http://www.nrs.fs.fed.us/fi a/data-tools/state-reports/default.asp.

Foreword Forests at a tipping pointOhio's forests are a critical component of the state's natural resources. Covering nearly 8 million acres, or 30 percent of the state, these diverse forests support important biological communities and create habitat for wildlife, forest products, clean water, and opportunities for recreation. Essential to making sound decisions about Ohio's forests is credible information. Forest Inventory and Analysis (FIA) data help fill this need. Such data tell us where we are and where we are going, and they provide the basis for making informed decisions about how we can sustain our forests for future generations.The fifth inventory of Ohio's forests suggests that we are at a tipping point. Ohio's forests hold more wood, provide more wildlife habitat, and store more carbon than 15 years ago. Yet, for the first time since the 1940s, the acreage of Ohio's forest land has not increased, and some parts of the state have seen large losses in forest cover. More Ohioans than ever own forest land and enjoy the many benefits that forests provide. But, as Ohio's forest lands are subdivided and fragmented, the ability of these forests to provide timber, wildlife habitat, recreation, and solitude is reduced. Oak-hickory forests make up over one-half of the state's forests. Oaks as seedlings and saplings, however, have declined in abundance, and oaks will likely play a smaller role in Ohio's future forests. The quality and value of our timber has increased during the past 15 years, and landowners intend to harvest trees on onefifth of Ohio's forested acres in the next 5 years. However, only 4 percent of forest landowners have a formal management plan for their forests, and fewer than one in seven seeks any sort of advice before making decisions that will affect them and their forests for decades.John F. Kennedy said: "It is our task in our time and in our generation, to hand down undiminished to those who come after us, as was handed down to us by those who went before, the natural wealth and beauty which is ours." The data presented in this report clearly highlight the challenges our forests face: fragmentation, uninformed management, loss of oak, invasive species, and a host of other concerns. How we address these concerns, how we balance forest conservation and sustainable use, will determine the forests that future generations experience and the benefits they receive. Doubtless, the FIA reports of tomorrow will document the successes, or the failures, of the choices we make today. IntroductionThis is the fifth inventory of Ohio's forests, the first using a new annualized inventory system. Previous inventories were completed for 1952 (Hutchison and Morgan 1956), 1968(Kingsley and Mayer 1970), 1979(Dennis and Birch 1981), and 1991(Griffith et al. 1993. These inventories provided a snapshot of the forest for specific periods in time after which no new information was available until the next full inventory of the State. Henceforth, inventory data for the State will be updated annually and full rem...