Absfrucf.A malignant teratoid medulloepithelioma that arose from the ciliary body was found in an adult Beagle. The anterior part contained relatively well-differentiated tumor cells, cartilage, and ganglion cells. These structures were interpreted as teratoid formations derived from the embryonic anlage of the medullary epithelium. The more posterior part was highly anaplastic and invasive. A transitional area contained neural rosettes of the Flexner-Wintersteiner type. This tumor is rare in both man and animals.Intraocular ciliary body tumors appear to be uncommon in man and in animals [7, 181. Of the tumors reported in dogs and other animals, however, ciliary body tumors represent a significant number of primary intraocular neoplasms [3, 191. Malignant teratoid tumor of the ciliary epithelium is rare in both animals and man. Its variable morphology makes diagnosis difficult but elucidates the embryogenesis of the ciliary epithelium. Clinical HistoryA 4-year-old Beagle bitch was examined for evaluation of a 'white pupil' in the left eye. This had been first noted 3 months previously. There was no history of ocular tumors or other malignancies in the litter. Three weeks before examination, the eye became proptotic. There was periorbital swelling, and hemorrhagic discharge was seen from a perforated cornea. A solid white mass partially filled the anterior chamber and extended behind the lens as well. Enucleation with partial removal of the orbital content was subsequently performed. Four years later there is no evidence of orbital recurrence.Gross examination showed a firm globe with an irregular solid mass penetrating the cornea at the limbus and at the posterior part of the globe. The anterior segment, vitreous cavity, retina, sclera and orbit were filled with a firm tumor. Microscopic examination
The genetically diabetic mouse (db/db) exhibits hyperphagia, progressive weight gain, hyperglycemia, and hyperinsulinemia during the first few months of life during which time characteristic pathologic changes occur in several organ systems including the kidney. The extent to which long chain fatty acid oxidation (LCFAO) contributes to excessive gluconeogenesis and hyperglycemia in these animals in unknown. Therefore, the synthetic fatty acid analogue 2-tetradeclyglycidate (TDHA), a potent inhibitor of LCFAO, was given orally to db/db mice to evaluate its capacity to control the blood glucose and prevent their diabetic nephropathy. Five groups of diabetic mice (N = 6) were assigned to receive TDGA in a dose of 5, 10, and 25 mg/kg/day, vehicle (tragacanth), or nothing (control). TDGA had no observable effects on food intake or growth patterns. Drug-treated animals had significant lowering of fasting glucose at 0 and 4 h after dosing during the midportion of the study (2-6 wk). In the latter part of the study (wk 8-11), blood glucose 4 h after dosing was lowered in mice given 10 and 25 free fatty acids. Animals receiving TDGA 25 mg/kg/day exhibited significant inhibition of immunopathologic changes in the kidney. Heart weight was significantly increased in mice receiving TDGA 25 mg/kg/day, and the total amount of myocardial carnitine content was increased in all three drug-treated groups. Increased tissue deposition of lipid was not apparent on histologic examination of liver in drug-treated animals. Inhibition of long chain fat oxidation in the db/db mouse results in significant lowering of blood glucose, and decreased the renal immunopathologic features of diabetic nephropathy in this animal model.
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