Novel bitriazolyl nucleosides were synthesized via the Huisgen reaction, starting with 3-azidotriazole nucleoside (1). Surprisingly, its isomer, 5-azidotriazole nucleoside (1') did not yield the corresponding Huisgen reaction products efficiently because it was rapidly reduced to amine in the presence of Cu(II)-ascorbate. The significant differences between the reactivity of these two isomers in Cu(II)-ascorbate mediated reactions are mainly due to differences in their electronic properties and steric congestion as a result of different relative positions of the azido and the ribosyl moieties.
Isothermal vepor-HqukS equilibrium data and excess volumes for 1-butanol and 2-methyl-1 -propanol In n-hexane were measured. The vapor-liquid equilibrium data were reduced according to the maximum likelihood principle. The parameters of NRTL, Wilson, and UNIQUAC equations were calculated and reported.
Isothermal P-x-y and excess volume data for 1-butanol and 2-methyl-1-propanol In -heptane are measured. The vapor-llquld equilibrium data were reduced according to the maximum likelihood principle. The parameters of NRTL, Wilson, and UNIQUAC equations were calculated and reported.
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