A highly regioselective
asymmetric hydroboration of 2H-chromenes catalyzed
by the complex of CuCl and diphosphine ligand
(S,R)-DuanPhos has been realized
under mild conditions to produce 3-boryl chromans, achieving good
yields and excellent enantioselectivities up to 96% ee. This work
provides an efficient approach to the synthesis of chiral 3-boryl
chromans and derivatives.
The first asymmetric hydrogenation of β,β-diaryl unsaturated phosphonates has been realized for synthesis of β,βdiaryl chiral phosphonates with excellent enantioselectivities (up to 99.9% ee) catalyzed by the Rh-(R,R)-f-spiroPhos complex. Furthermore, this catalyst also exhibits comparably excellent performance for β-aryl-β-alkyl unsaturated phosphonates providing the corresponding chiral phosphonates with up to 99.9% ee values. This methodology provides a straightforward access to asymmetric synthesis of chiral phosphonates. Article pubs.acs.org/joc
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