Objective. This study was conducted to compare the efficacy of standard therapy (radiotherapy/RT/CT) with that of antiepidermal growth factor receptor (anti-EGFR) monoclonal antibody (NPC) therapy in patients with advanced nasopharyngeal cancer. Methods. A meta-analysis was performed to meet the objective of this study. The English databases PubMed, Cochrane Library, and Web of Science were searched. The literature review compared anti-EGFR-targeted therapy with conventional therapy practices. The main outcome measure was overall survival (OS). Secondary goals were progression-free survival (PFS), locoregional recurrence-free survival (LRRFS), distant metastasis-free survival (DMFS), and adverse events (grade 3). Results. The database search resulted in 11 studies, with a total of 4219 participants. It was found that combining an anti-EGFR regimen with conventional therapy did not enhance OS ( hazard ratio HR = 1.18 ; 95 % confidence interval CI = 0.51 – 2.40 ; p = 0.70 ) or PFS appreciably ( HR = 0.95 ; 95 % CI = 0.51 – 1.48 ; p = 0.88 ) in patients with nasopharyngeal carcinoma. While LRRFS increased considerably ( HR = 0.70 ; 95 % CI = 0.67 – 1.00 ; p = 0.01 ), the combined regimen did not improve DMFS ( HR = 0.86 ; 95 % CI = 0.61 – 1.12 ; p = 0.36 ). Treatment-related adverse events included haematological toxicity ( RR = 0.2 ; 95 % CI = 0.08 – 0.45 ; p = 0.01 ), cutaneous reactions ( RR = 7.05 ; 95 % CI = 2.15 – 23.09 ; p = 0.01 ), and mucositis ( RR = 1.96 ; 95 % CI = 1.58 – 2.09 ; p = 0.01 ). Conclusions. Individuals who have nasopharyngeal cancer do not have an increased chance of surviving until a local recurrence of their disease if they get normal therapy in addition to an anti-EGFR regimen. However, this combination does not enhance overall survival. On the other hand, this factor adds to an increase in the number of adverse effects.
In this paper, an underwater detection robot with the three-level control mode of ROV/ARV/AUV is proposed, aiming at the safety measurement of complex hydraulic structures such as long-distance water conveyance tunnel of pumped storage power station. In normal operation, the power supply and control of the underwater robot body is completed by the surface equipment through the umbilical cable (ROV mode).When the cable is wound, the robot releases the cable box, which is powered by a battery. The surface operator controls the robot through the built-in fiber optics of robot (ARV mode). Extremely, the optical fiber connection is interrupted, the robot will automatically return to initial position according to the guidance sonar (AUV mode). Finally, the control function tests and the independent return-to-navigation reliability verification are carried out in the real hydropower plant environment. 1
With the development of domestic petrochemical enterprises, the need of the import equipment is increasing, so the training for the worker is extremely urgent. This paper designs a set of simulation training hardware system, using the current material resources, according to the configuration file free configuration, so as to reduce the development cost, to speed up the development speed and efficiency. At present the simulation system has been used in domestic petrochemical enterprises, and achieved good economic and social benefits.
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