The Max Planck Institute Grand Ensemble (MPI-GE) is the largest ensemble of a single comprehensive climate model currently available, with 100 members for the historical simulations and four forcing scenarios. It is currently the only large ensemble available that includes scenario representative concentration pathway (RCP) 2.6 and a 1% CO 2 scenario. These advantages make MPI-GE a powerful tool. We present an overview of MPI-GE, its components, and detail the experiments completed. We demonstrate how to separate the forced response from internal variability in a large ensemble. This separation allows the quantification of both the forced signal under climate change and the internal variability to unprecedented precision. We then demonstrate multiple ways to evaluate MPI-GE and put observations in the context of a large ensemble, including a novel approach for comparing model internal variability with estimated observed variability. Finally, we present four novel analyses, which can only be completed using a large ensemble. First, we address whether temperature and precipitation have a pathway dependence using the forcing scenarios. Second, the forced signal of the highly noisy atmospheric circulation is computed, and different drivers are identified to be important for the North Pacific and North Atlantic regions. Third, we use the ensemble dimension to investigate the time dependency of Atlantic Meridional Overturning Circulation variability changes under global warming. Last, sea level pressure is used as an example to demonstrate how MPI-GE can be utilized to estimate the ensemble size needed for a given scientific problem and provide insights for future ensemble projects.Large-ensemble projects of comprehensive coupled climate models are gaining traction as methods to robustly estimate internal variability in transient simulations and to quantify the forced signal (e.g., Kay

Oral keratinocytes had good biocompatibility with bladder acellular matrix grafts. Urethral reconstruction with these grafts was better than with bladder acellular matrix grafts alone.

Climate models project that extreme precipitation events will intensify in proportion to their intensity during the 21st century at large spatial scales. The identification of the causes of this phenomenon nevertheless remains tenuous. Using a large ensemble of North American regional climate simulations, we show that the more rapid intensification of more extreme events also appears as a robust feature at finer regional scales. The larger increases in more extreme events than in less extreme events are found to be primarily due to atmospheric circulation changes. Thermodynamically induced changes have relatively uniform effects across extreme events and regions. In contrast, circulation changes weaken moderate events over western interior regions of North America and enhance them elsewhere. The weakening effect decreases and even reverses for more extreme events, whereas there is further intensification over other parts of North America, creating an “intense gets intenser” pattern over most of the continent.