Parameter tuning, that is, to find appropriate parameter settings (or configurations) of algorithms so that their performance is optimized, is an important task in the development and application of metaheuristics. Automating this task, i.e., developing algorithmic procedure to address parameter tuning task, is highly desired and has attracted significant attention from the researchers and practitioners. During last two decades, many automatic parameter tuning approaches have been proposed. This paper presents a comprehensive survey of automatic parameter tuning methods for metaheuristics. A new classification (or taxonomy) of automatic parameter tuning methods is introduced according to the structure of tuning methods. The existing automatic parameter tuning approaches are consequently classified into three categories: 1) simple generateevaluate methods; 2) iterative generate-evaluate methods; and 3) high-level generate-evaluate methods. Then, these three categories of tuning methods are reviewed in sequence. In addition to the description of each tuning method, its main strengths and weaknesses are discussed, which is helpful for new researchers or practitioners to select appropriate tuning methods to use. Furthermore, some challenges and directions of this field are pointed out for further research.

Coronavirus disease 2019 (COVID-19) remains a major health challenge globally. Previous studies have suggested that changes in the glycosylation of IgG are closely associated with the severity of COVID-19. This study aimed to compare the profiles of IgG N-glycome between COVID-19 patients and healthy controls. A case-control study was conducted, in which 104 COVID-19 patients and 104 age- and sex-matched healthy individuals were recruited. Serum IgG N-glycome composition was analyzed by hydrophilic interaction liquid chromatography with the ultra-high-performance liquid chromatography (HILIC-UPLC) approach. COVID-19 patients have a decreased level of IgG fucosylation, which upregulates antibody-dependent cell cytotoxicity (ADCC) in acute immune responses. In severe cases, a low level of IgG sialylation contributes to the ADCC-regulated enhancement of inflammatory cytokines. The decreases in sialylation and galactosylation play a role in COVID-19 pathogenesis via the activation of the lectin-initiated alternative complement pathway. IgG N-glycosylation underlines the complex clinical phenotypes of SARS-CoV-2 infection.

No abstract

Artificial intelligence (AI) has profoundly changed and will continue to change our lives. AI is being applied in more and more fields and scenarios such as autonomous driving, medical care, media, finance, industrial robots, and internet services. The widespread application of AI and its deep integration with the economy and society have improved efficiency and produced benefits. At the same time, it will inevitably impact the existing social order and raise ethical concerns. Ethical issues, such as privacy leakage, discrimination, unemployment, and security risks, brought about by AI systems have caused great trouble to people. Therefore, AI ethics, which is a field related to the study of ethical issues in AI, has become not only an important research topic in academia, but also an important topic of common concern for individuals, organizations, countries, and society. This paper will give a comprehensive overview of this field by summarizing and analyzing the ethical risks and issues raised by AI, ethical guidelines and principles issued by different organizations, approaches for addressing ethical issues in AI, methods for evaluating the ethics of AI. Additionally, challenges in implementing ethics in AI and some future perspectives are pointed out. We hope our work will provide a systematic and comprehensive overview of AI ethics for researchers and practitioners in this field, especially the beginners of this research discipline.Impact Statement-AI ethics is an important emerging topic among academia, industry, government, society, and individuals. In the past decades, many efforts have been made to study the ethical issues in AI. This article offers a comprehensive overview of the AI ethics field, including the summary and analysis of AI ethical issues, ethical guidelines and principles, approaches to address AI ethical issues, and methods to evaluate the ethics of AI. Additionally, some challenges and future perspectives are discussed. This article will help researchers to obtain sufficient background and a bird's eye view of AI ethics, and thus facilitate their further investigation and research.