Quercetin-iron (II) complex was synthesized and characterized by elemental analysis, ultraviolet-visible spectrophotometry, fourier transform infrared spectroscopy, mass spectrometry, proton nuclear magnetic resonance spectroscopy, thermogravimetry and differential scanning calorimetry, scanning electron micrography and molar conductivity. The low molar conductivity value investigates the non-electrolyte nature of the complex. The elemental analysis and other physical and spectroscopic methods reveal the 1:2 stoichiometric ratio (metal:ligand) of the complex. Antioxidant study of the quercetin and its metal complex against 2, 2-di-phenyl-1-picryl hydrazyl radical showed that the complex has much more radical scavenging activity than free quercetin. The interaction of quercetin-iron (II) complex with DNA was determined using ultraviolet visible spectra, fluorescence spectra and agarose gel electrophoresis. The results showed that quercetin-iron (II) complex can intercalate moderately with DNA, quench a strong intercalator ethidium bromide and compete for the intercalative binding sites. The complex showed significant cleavage of pBR 322 DNA from supercoiled form to nicked circular form and these cleavage effects were dose-dependent. Moreover, the mechanism of DNA cleavage indicated that it was an oxidative cleavage pathway. These results revealed the potential nuclease activity of complex to cleave DNA. In addition, antibacterial activity of complex on E.coli and S. aureus was also investigated. The results showed that complex has higher antibacterial activity than ligand.
Three N-H functionalized metal-organic frameworks, Pb-DDQ, Zn-DDQ, and Cu-DDQ, were synthesized with a new flexible dicarboxylate ligand based on quinoxaline (H2DDQ = N,N'-dibenzoic acid-2,3-diaminoquinoxaline). CO2 adsorptions indicate that Zn-DDQ and Cu-DDQ have greatly enhanced the CO2 uptake due to the opposite N-H groups on pyrazine. With very small adsorption of N2, Cu-DDQ shows high selectivity for CO2 and N2. The three MOFs also have large adsorptions of some selected dyes, while Zn-DDQ and Cu-DDQ with large but different shapes of pores are demonstrated to be promising materials for fast separation of MB/other and CV/other mixtures, respectively. The cyanosilylation of aldehydes and ketones with high yields in a short reaction time for Cu-DDQ indicates that Cu-DDQ has a higher Lewis acidity than the other two MOFs.
Six inorganic-organic compounds based on [Mo x O y ] nchains, [Ag 2 (quinoxaline) 2 Mo 4 O 13 ] (1), [Cu 2 (DMPz) 2 Mo 4 O 13 ] (2) (DMPz ) 2,5-dimethylpyrazine), [Cu 2 (4-PBIM) 2 Mo 4 O 13 ] (3) [4-PBIM ) 2-(4-pyridyl)benzimidazole], [Cu(OPBIM)(H 2 O) Mo 3 O 10 ]‚H 2 O (4) [OPBIM ) 2-(2-ol-3-pyridinio)benzimidazole], [Co(3-HPBIM) 2 (H 2 O) 2 Mo 6 O 20 ] (5) [3-HPBIM ) 2-(3-pyridyl)benzimidazolium], [Ni(3-HPBIM) 2 (H 2 O) 2 Mo 6 O 20 ] (6), have been hydrothermally synthesized and characterized by single-crystal X-ray diffraction. Compounds 1 and 2 represent the first two examples of three-dimensional frameworks constructed from [Mo 8 O 26 ] n 4nanion chains integrated by M-L polymeric cation chains. Compounds 3 and 4 reveal the peripheral decorated [Mo 8 O 26 ] n 4nand [Mo 3 O 10 ] n 2none-dimensional chains, respectively. The isostructural compounds 5 and 6 feature two-dimensional networks formed from [Mo 3 O 10 ] 2n 4ninfinite chains linked by [Co(3-HPBIM) 2 ] 4+ fragments. The molybdate chains in compounds 1-3 and 4-6 represent three isomeric forms of [Mo 8 O 26 ] n 4nand two [Mo 3 O 10 ] n 2nchains, respectively.
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