Electrochemical oxidative regioselective C−H cyanation of imidazo[1,2-a]pyridines was developed using readily available TMSCN as the cyano source. The KH 2 PO 4 /K 2 HPO 4 buffer was essential for this transformation. This protocol was compatible with a broad range of substituted imidazo[1,2a]pyridines and provided the C3 cyanated products in moderate to excellent yields.
Dioxygenation of alkenes was developed
by the combination of electrochemical
synthesis and aerobic oxidation, leading to easy accessibility of
α-oxygenated ketones in an eco-friendly fashion. Using air as
the oxygen source and the absence of transition metals were the critical
features of this protocol. A wide range of alkenes and N-hydroxyimides were found to be compatible and provided α-oxygenated
ketones in moderate to high yields.
Direct C–H silylation of quinoxalinones was achieved by the combination of organic photoredox catalysis and hydrogen atom transfer (HAT) under ambient air conditions.
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