A Clerodane Diterpene with Antibacterial Activity from Ajuga lupulina.-The stereochemistry of the title compound (I) is established by comparison with the absolute configuration of ajugareptansin, clerodin, and ajugarins IV and V. The structure has the two six-membered rings in ideal chair conformation and is stabilized by intramolecular hydrogen bonds. -(CHEN, H.; TAN, R.-X.; LIU, Z.-L.; ZHAO, C.-Y.; SUN, J.; Acta Crystallogr., Sect. C: Cryst.
Twenty-one novel N,4-diphenylpyrimidin-2-amine derivatives have been synthesized as PI3Kγ selective inhibitors and compound C8 demonstrated the most potent inhibitory activity against PI3Kγ kinase.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.