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Angiogenesis is required for tumor growth. Dihydroartemisinin (DHA), a the effective anti-malarial derivative of artemisinin, demonstrated potent anti-angiogenic activities that closely related to the regulation of vascular endothelial growth factor (VEGF) signaling cascade. VEGF receptor 1 (VEGFR1), a receptor in endothelial cells (ECs), coordinately regulate angiogenic activity triggered by ligand-receptor binding. Here we aimed to explore the effects of DHA on VEGFR1 expression in ECs. We found that DHA significantly increases VEGFR1 expression in human umbilical vein endothelial cells (HUVECs). In addition, DHA significantly upregulates the level of V-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog 1 (ETS-1), a transcriptional factor which binds to the human VEGFR1 promoter. ChIP assay showed that DHA increases ETS-1 binding to the -52 ETS motif on the VEGFR1 promoter. Knockdown of ETS-1 by RNA interference abolished DHA-induced increase of VEGFR1 expression. Taken together, we demonstrated that DHA elevates VEGFR1 expression via up-regulation of ETS-1 transcription in HUVECs.

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This The article proposes a new approach of measuring the object's relative displacement vector on the earth's surface and develops measuring circuit and data processing circuit.We use three magnetic sensors which are mutually vertical and dedicated chip PNI11096 to measure. The three magnetic sensors all have their respective magentic circuit and temperature-compensation circuit and the antiinterference circuit.PNI11096 opens data register for magnetic sensor. Under the control of PNI11096,the three magnetic sensors measure the three mutually perpendicular component data of X, Y, Z.And then the sensors convey results to SCM by SPI interface. System storages the earth's magnetic field intensity data of the departure A0 and the destination A1 while measuring. So get the changes of the earth's magnetic flux density .Therefore,we can calculate the object's relative displacement vector.The article analyses the interfrence factors in the measurement process and the corresponding disposal methods.Finally,the paper describes the technology's applicate prospect.