Of the functional and anatomic outcome variables, circadian MOPP fluctuation was the most consistent clinical risk factor for glaucoma severity in eyes with NTG. This finding may suggest an etiology of NTG as a chronic ischemic end organ disease.

Inspiralling black hole-neutron star (BH-NS) binaries emit a complicated gravitational wave signature, produced by multiple harmonics sourced by their strong local gravitational field and further modulated by the orbital plane's precession. Some features of this complex signal are easily accessible to ground-based interferometers (e.g., the rate of change of frequency); others less so (e.g., the polarization content); and others unavailable (e.g., features of the signal out of band). For this reason, an ambiguity function (a diagnostic of dissimilarity) between two such signals varies on many parameter scales and ranges. In this paper, we present a method for computing an approximate, effective Fisher matrix from variations in the ambiguity function on physically pertinent scales which depend on the relevant signal to noise ratio. As a concrete example, we explore how higher harmonics improve parameter measurement accuracy. As previous studies suggest, for our fiducial BH-NS binaries and for plausible signal amplitudes, we see that higher harmonics at best marginally improve our ability to measure parameters. For non-precessing binaries, these Fisher matrices separate into intrinsic (mass, spin) and extrinsic (geometrical) parameters; higher harmonics principally improve our knowledge about the line of sight. For the precessing binaries, the extra information provided by higher harmonics is distributed across several parameters. We provide concrete estimates for measurement accuracy, using coordinates adapted to the precession cone in the detector's sensitive band.

Precessing black hole-neutron star (BH-NS) binaries produce a rich gravitational wave signal, encoding the binary's nature and inspiral kinematics. Using the lalinference_mcmc Markov chain Monte Carlo parameter estimation code, we use two fiducial examples to illustrate how the geometry and kinematics are encoded into the modulated gravitational wave signal, using coordinates well adapted to precession. Extending previous work, we demonstrate that the performance of detailed parameter estimation studies can often be estimated by "effective" studies: comparisons of a prototype signal with its nearest neighbors, adopting a fixed sky location and idealized two-detector network. Using a concrete example, we show that higher harmonics provide nonzero but small local improvement when estimating the parameters of precessing BH-NS binaries. We also show that higher harmonics can improve parameter estimation accuracy for precessing binaries by breaking leading-order discrete symmetries and thus ruling out approximately degenerate source orientations. Our work illustrates quantities gravitational wave measurements can provide, such as the orientation of a precessing short gamma ray burst progenitor relative to the line of sight. More broadly, "effective" estimates may provide a simple way to estimate trends in the performance of parameter estimation for generic precessing BH-NS binaries in next-generation detectors. For example, our results suggest that the orbital chirp rate, precession rate, and precession geometry are roughly independent observables, defining natural variables to organize correlations in the highdimensional BH-NS binary parameter space.

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