Although liquid crystal (LC) systems have been studied before, their utility in drug delivery applications has not been explored in depth. This study examined the development of a 1-month sustained release formulation of leuprolide acetate using an in situ-forming LC matrix. The phase progression upon water absorption was tested through construction of ternary phase diagrams of phosphatidylcholine, sorbitan monooleate, and tocopherol acetate (TA) at increasing water content. Small angle X-ray scattering revealed the presence of lamellar and hexagonal mesophases. The physicochemical characteristics and in vitro drug release were evaluated as a function of the ternary component ratio and its resultant phase behavior. Formulations with increased water uptake capacity displayed greater drug release and enhanced erodability. Removal of TA resulted in increased water uptake capacity and drug release, where 8% (w/w) TA was determined as the critical concentration threshold for divergence of release profiles. In conclusion, characterization of the resultant H mesophase region provided information of the impact the individual components have on the physicochemical properties and potential drug release mechanisms. This high mitigating impact of TA on drug release indicates the use of TA as a tailoring agent, broadening the therapeutic applications of this LC system.
The downstream of the Nam River Dam is crucial region for long-term water resource planning for Busan and Gyeongnam Province. Thus, the analysis of flow behavior and water quality is necessary for the sustainable surface water management and the control of pollutant source. In this study, the flow field and BOD transport at the downstream of Nam River Dam were analyzed by incorporating 2-D water quality model, RAM4 and 3-D water quality model, WASP with the hydrodynamic model, RAM2 and EFDC, respectively. The application of 2-D flow analysis model, RAM2 showed that velocity distributions at the five transverse sections of the meandering part closely followed the measured values by ADCP, and the flow field and overflow characteristic at the submerged weir showed satisfactory performance compared with the result of 3-D EFDC model. In addition, the BOD concentration field obtained by RAM2-RAM4 coupled modeling was in good agreement with the result by EFDC-WASP model throughout the computational domain. The hydrodynamic characteristic and water quality at the downstream reach of Nam River Dam are mainly influenced by the Dam discharge, and the water quantity is closely related to the water quality control and fishery environment at the lower part of Nakdong River. Therefore, when further quantitative analysis is necessary regarding these issues, 2-D semi-coupled modeling is recommended in terms of computational effectiveness and model application aspect.
A B S T R A C T KEYWORDSThe opportunity provided for design method and strategy of sustainable campus on the waterfront, is the purpose of this paper. Waterfront campus is an important issue as it seeks to revive the sustainability and to renew the facilities. This paper reviews an assessment of its success for waterfront campus in 10 principles such as waterfront,
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.