Gastrointestinal stromal tumours (GIST) are the most common mesenchymal tumours of the gastrointestinal tract. They constitute a significant percentage ranging from 1-2 % of all the gastrointestinal neoplasms [11]. Knowledge on the molecular biology and behavior of these tumours is still not very clear. The clinicopathologial features are variable and surgical resection with chemotherapy is the main modality of treatment. We have retrospectively analyzed the clinicopathological features, treatment and prognosis of 150 patients managed in the Department of Surgery. Retrospective review of the records of 150 patients diagnosed with gastrointestinal stromal tumours and managed during the period January 2006 to December 2011. Clinicopathological features, immunohistochemistry, mitotic index, surgical resection adjuvant chemotherapy and survival analyzed. One hundred and fifty patients diagnosed with GIST and treated were reviewed. Ninety five of them were males (63.3 %). The tumour was most commonly seen during the fourth and fifth decades of life. Abdominal pain (52 %), intestinal bleeding (40 %) and abdominal mass (25 %) were the common clinical symptoms. Sixty percent of the tumours (90/150) were located in the stomach followed by small bowel (20 %) and duodenum (14.6 %). One hundred and thirty-five patients underwent excision of the tumour and five patients had multi organ resection of the adjacent organs like spleen, tail of the pancreas and kidney.
Introduction: Neuroendocrine tumors develop throughout gastrointestinal tract. The concurrence of mixed adenocarcinoma and neuroendocrine tumor together in the stomach is rare. Case report:We report two cases of poorly differentiated carcinoma stomach with neuroendocrine component. These patients underwent radical total gastrectomy with D2 lymph node dissection followed by adjuvant chemotherapy. They are asymptomatic and disease free on follow -up. Conclusion:Combination of neuroendocrine tumours and adenocarcinoma stomach a rare entity. Pre operative diagnosis with endoscopic biopsy is difficult. However, if there is a suspicion based on endoscopic biopsy, and then Immunohistochemical staining for neuroendocrine tumor markers may help in establishing preoperative diagnosis.
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