INTRODUCTION β-glucans are glucose polymers with a backbone of linear β(1,3)-linked D-glucose molecules, branching β(1,6)-linked side chains of diverse sizes and at different intervals along the backbone. Among the β-glucans with β(1,3), β(1,4) and β(1,6) linkages, only β(1,3) β-glucan is immuno-stimulatory. Barley β-glucans have primarily β(1,4) linkages, whereas the fungal β-glucans have a β(1,3) backbone branched with short β(1,6)-linked side chains. 1,2 Zymosan-a mixture of β(1,3) (1,6) glucans and mannose, is a crude cell wall extract of the yeast Saccharomyces cerevisiae. The β-glucan molecular
Type II transmembrane serine protease (TMPRSS2) is expressed at the cell surface with COVID-19 infection. And COVID-19 infection misuse TMPRSS2 to advance their spread, making this protease potential focuses for intervention in COVID-19 infection. TMPRSS2 blocker may be the appropriate option to arrest cellular entry of COVID-19 by deregulating spike priming. Therefore a trial may be intended to watch the adequacy of aerosolized spraying of TMPRSS2 inhibitors to break the viral entry to the objective cells that empower to break the COVID-19 transmission. Targeting TMPRSS2 through aerosolized TMPRSS2 inhibitor is important to examine a possibly viable remedial technique in the treatment of COVID-19.
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