Abbreviations: EMSA, electrophoretic mobility shift assay; HCE, human corneal epithelial cells; iNOS, inducible nitric oxide synthase; NF-κB, nuclear factor-κB clearly dem onstrated that β-defensin 1 and 2 are im p o rtan t an tim icro b ial p ep tid es in th e co rn eal tissues, and th at the m echanistic in duction pro cess of β-defen sin 2 by IL-1β is n o t so lely depend en t o n proxim al N F-κB site activation, thus sugg esting that the long distal portion of th e p ro m o ter is n eed ed fo r th e fu ll resp o nsiveness to w ard IL-1β.
A bstractRecent epidem iological studies suggest that alcohol consum ption is one of the risk factors leading to type 2 diabetes, but the direct effect of ethanol on β-cell gene expression is not know n. Here, using cDNA RDA m ethod, w e isolated 43 ethanolinduced genes in pancreatic β-cells,
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