Herbal medicine is a traditional drink made from natural ingredients for human health and is made with methods and equipment that are easier in its simplicity which often does not pay attention to hygiene factors and can be a medium for disease transmission. Based on the Regulation of the Head of the Republic of Indonesia Drug and Food Control Agency No. 12 of 2014 concerning requirements for drug fluids in the form of microbial contamination / ALT ≤104 colonies/ml. The purpose of this study was to study the estimated numbers of traditional herbs sold in the Tulungagung District market. The research design used is descriptive. The sampling technique uses a total sampling technique of 6 samples from 4 different markets. Sample meeting with the ALT method in May 2018 in the microbiology laboratory of STIKes Hutama Abdi Husada Tulungagung. The results of the study found that three out of six samples of traditional herbal medicine of kencur rice exceeded the microbial contamination threshold with an average yield of 1 x 107 CFU / ml. The study concludes is that 50% of the sample is not suitable for consumption and 50% of the sample is suitable for consumption. This requires Regulation of BPOM RI Number 12 the year 2014 Regarding Quality Requirements for Traditional Medicines, namely ≤104 colonies/ml. Herbal traders need to pay attention to raw materials, processing, equipment, air used, and containers used.

Tuberculosis (TB) is one of the major causes of death. In the report of Tuberculosis Global 2014 which was realeased by

Drinking water that is consumed should be clean and healthy. To avoid illness and disruption of bodily functions such as kidney function, liver, brain, teeth, and even mental disorders. Some people in Besole village still use dug well water as a source of drinking water. The geographical state of the town of Besole, Tulungagung district, is a mountainous area of marble containing lime which allows for mineral content, main calcium in the drinking water of residents. This study aims to determine the identification of urine sediments in residents who consume well water in Besole Village, Besuki District, Tulungagung Regency in 2018. This type of research is descriptive non-analytic, by determining the percentage of urine sediments that consume well water through an examination at the Pathology Laboratory STIKes Hutama Abdi Husada Tulungagung. The number of samples is 30 people, with simple random sampling technique. Based on the research conducted found the results of abnormal urine sediment percentage, ie, 6.7% leukocytes, 3.3% erythrocytes, 16.7% epithelium, 30% calcium oxalate and 3.3% bacteria. Water containing lime should be boiled, precipitated and filtered before consumption.

Infectious diseases caused by bacteria in generals can be cured using antibacterial. The use of antibacterials tends to cause local hypersensitivity either on the skin or mucous membranes so that their use is starting to be reduced. Therefore, the development of natural antibacterials made from plants to reduce resistance is very necessary. kecombrang (Etlingera elatior) is one of the plants that has been shown to have activity in inhibiting bacterial growth. This research is an experimental study that aims to determine the effectiveness of the ethanol extract of the leaves of kecombrang in inhibiting the growth of Klebsiella pneumoniae bacteria in vitro. The method used is the well method with a completely randomized design. The sample came from the Klebsiella pneumoniae bacteria culture. Kecombrang leaf ethanol extract was made in concentrations of 20%, 40%, 60%, 80% and 100%. The extract was tested on Klebsiella pneumoniae bacteria and observed for the formation of inhibition zones. Inhibition the results of the zone measuremens were then analyzed descriptively. The results showed kecombrang leaf ethanol extract 20%, 40%, 60%, 80%, and 100% produce inhibition zone diameter 1.9 mm; 2.6 mm; 7.7 mm; 12.1 mm; and 14.7 mm, 0.4 mm for the negative control and positive control 22.0 mm. Concentration 100% has better antibacterial ability due to higher compound content. The test results show the class of secondary metabolites kecombrang leaf ethanol extract contains flavonoids, tannin, and saponin. The conclusion of this study that the ethanol extract of kecombrang leaves has potential to inhibit the growth of Klebsiella pneumoniae bacteria.

ABSTRAKTuberculosis merupakan penyakit menular yang menjadi perhatian global yang disebabkan oleh infeksi bakteri Mycobacterium tuberculosis, menyerangpada paruparu maupun organorgan lainnya seperti hati, ginjal, tulang ataupun kulit. Bila seseorangterinfeksi tuberculosis maka tubuh akanterjadi proses inflamasi,inflamasi tersebut dapat menimbulkan manifestasi hematologi. Tujuan penelitian ini adalah untuk mengetahui gambaran jumlah leukosit danLaju Endap Darah (LED) pada pasien tuberculosis. Desain penelitian yang digunakan adalah deskriptif non analitik. Populasi dalam penelitian ini adalah semua pasien tuberculosis di Rumah Sakit Paru Dungus Madiun Tahun 2018. Dengan menggunakan teknik Quota Sampling, sampel pada penelitian ini sebanyak 30 responden. Penelitian ini dilakukan pada bulan Mei 2018. Hasil dari penelitian pada pasien tuberculosis diperoleh gambaran jumlah leukosit pada penderita TB adalah 9120 sel/µL darah, 11 (37%) penderita mengalami leukositosis dan 19 (63%) penderita memiliki jumlah leukosit yang nomal. Jumlah leukosit terendah adalah 4100 sel/µL darah dan tertinggi 24700 sel/µL darah. Nilai rata-rata LED pada penderita TB adalah 71 mm/jam I, 29 (96,6%) penderita mengalami peningkatan nilai LED dan 1 (3,4%) penderita memiliki nilai LED normal. Nilai terendah LED adalah 11 mm/jam I dan nilai tertinggi LED adalah 106 mm/jam I. Pencegahan infeksi tuberculosis dapat dilakukan dengan melakukan pemeriksaan diagnosa laboratorium untuk mengetahui seberapa jauh perjalanan penyakitnya dan memilih OAT yang tepat untuk pasien. Dengan pengobatan yang intensif maka akan menurunkan jumlah leukosit dan mengurangi risiko untuk TB MDR. Kata kunci : jumlah leukosit, laju endap darah (LED), TuberculosisABSTRACT Tuberculosis is an infectious disease of global concern caused of bacterium Mycobacterium tuberculosis. It can attack lung, liver, kidneys, bones or skin. If a person infected by tuberculosis, the body will begin the mechanism of inflammation as a form of haematological manifestation. The purpose of this study was to describe the number of leukocytes and Blood Sedimentation Rate (BSR) in tuberculosis patients. The research design used is non-analytic descriptive. The population in this study were all tuberculosis patients at the Dungus Madiun Lung Hospital in 2018Using the Quota Sampling technique, the sample in this study was 30 respondents. This research was conducted on May 2018. The results of the study on tuberculosis patients showed that the number of leukocytes in TB patients was 9120 cells/µL blood, 11 (37%) patients had leukocytosis and 19 (63%) sufferers have a nominal leukocyte count. The lowest leukocyte count was 4100 cells/µL of blood and the highest was 24700 cells/µL of blood. The average value of BSR in TB patients was 71 mm/hour I, 29 (96.6%) patients experienced an increase in BSR values and 1 (3.4%) patients had normal BSR values. The lowest value of BSR is 11 mm/hour I and the highest value of BSR is 106 mm/hour I. Prevention of tuberculosis infection can be done by conducting laboratory...