Prostaglandins (PGs) are key regulatory factors that affect bone metabolism. Prostaglandin E 2 (PGE 2 ) regulates bone resorption and bone formation. Prostacyclin (PGI 2 ) is one of the major products derived from arachidonic acid by the action of cyclooxygenase and PGI 2 synthase (PGIS). Unlike PGE 2 , there are few reports about the role of PGI 2 in bone regulation. Therefore, we investigated the potential effect of PGI 2 on bone metabolism. We used PGIS knockout (PGIS K/K ), PGIS heterozygous (PGIS C/K
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