The home has become a new physical workplace, and can therefore influence the work, health, and life of workers. This cross-sectional study aimed to evaluate the chronology of the effects of work hazards at home on factors such as workers' health, productivity, and well-being (WB). Information on novice working-from-home (WFH) workers was derived from the "Occupational health of WFH" project. The selected variables in the hypothesis model comprised problems such as perceived indoor environmental quality (IEQ), working conditions (WC), sick house syndrome (SHS), occupational stress (OS), work productivity (WP), and WB. The relationship between these variables was analyzed using a structural equation model. The group analysis results showed the following significant indirect path effects from work environment through WP: IEQ-> SHS->OS->WP. A non-significant direct effect was observed between IEQ and WP. While WC problems could also have a significant direct effect on WP, or be mediated by OS, WP is a significant consequence and a direct effect of WB. In conclusion, the WFH model's causal impact between home environment, WP, and WB is a physiopsychological pathway. Therefore, creating a healthy home environment and WC, along with OS management, comprise important issues for improving productivity and WB for this new work style.
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