Herein, the synthesis of 3-(3-(substituted benzylidine)amino)phenyl-2-phenylquinazolin-4(3H)-ones
from 3-aminophenyl-2-phenyl-quinazolin-4(3H)-ones is reported. The chemical structures of the
synthesized compounds were confirmed by FT-IR, 1H NMR and 13C NMR studies. All compounds
were evaluated for their anticonvulsant activity against maximal electroshock seizure method. The
LD50 value was found to be 550 mg/Kg and the duration of tonic phase was reduced upto 1.1 s and that
of stupor phase was reduced upto 70 s. The structure activity relationship of the compounds revealed
that Schiff bases viz. 3-(3-benzylidineamino)phenyl-2-phenylquinazolin-4(3H)-one, 3-(3-(3-
chlorobenzylidine)amino)phenyl-2-phenylquinazolin-4(3H)-one, 3-(3-(3-
nitrobenzylidine)amino)phenyl-2-phenylquinazolin-4(3H)-one by significantly shorten the tonic and
stupor phases of convulsions compared to controls, thus thereby these compounds demonstrated strong
anticonvulsant potential.
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