The absolute configuration of the naphthylisoquinolines isoancistrocladine and isohamatine at the biaryl axis was determined by comparing the measured and the calculated CD spectra.In order to calculate these spectra we used the CNDO/S method in combination with a Boltzmann weighting of conformers with different dihedral angles at the biaryl axis. The Boltzmann factors were obtained with the AM 1 method.
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