A short, simple and economical process for large-scale preparation of nabumetone has been developed. The single-crystal structures of nabumetone and one of its key intermediates have been determined by X-ray diffraction studies. Two impurities have been isolated and characterised.

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ethers ethers (naphthalene compounds) Q 0890 -105Process Research and Structural Studies on Nabumetone.-A short, simple and economical process for the large-scale preparation of the drug nabumetone (IV) is described. The single crystal structures of (IV) and its key intermediate (III) are determined by X-ray diffraction studies. -(PRABHAKAR, C.; REDDY, G. BAKKI; REDDY, CH. MAHEEDHARA; NAGESHWAR, D.; DEVI, A. SIVALAKSHMI; BABU, J. MOSES; VYAS, K.; SARMA, M. R.; REDDY, G. OM; Org. Process Res. Dev. 3 (1999) 2, 121-125; Dep. Process Res. Dev., Dr. Reddy's Res. Found.,

Synthesis and Biological Activity of Novel Thiazolidinediones. -A series of novel compounds which combine a thiazolidinedione pharmacophore of antidiabetic drugs and a methoxynaphthyl pharmacophore of antiinflammatory drug nabumetone such as (III)/(IV), (VI), (IX) and (X) are synthesized and evaluated for their biological activity. Structure-activity relationships are discussed. -(PRABHAKAR, C.; MADHUSUDHAN, G.; SAHADEV, K.; REDDY, CH. M.; SARMA, M. R.; REDDY, G. O.; CHAKRABARTI, R.; RAO, C. S.; KUMAR, T. D.; RAJAGOPALAN, R.; Bioorg. Med. Chem. Lett.