Summary: A controlled clinical trial was carried out to test the effectiveness of a comparatively low dose of anti-D immunoglobulin (250 pg) in preventing rhesus immunization.In the control group 17 out of 329 women (5%) formed rhesus antibodies, whereas in the treated group only 3 out of 333 women (0.9%) showed active immunization, all three of whom had an exceptionally large transplacental bleeding.

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Abstract. A review of the present knowledge of transplacental transmission of anti‐neutrophil antibodies is given. A family in which one, possibly two of the three children had severe neutropenia after birth with subsequent infections, is described. An agglutinating antibody, directed against the neutrophil‐specific antigen NA 1, was demonstrated in the maternal serum. The father and all three children were NA 1‐positive. This case is another example of isoimmune neonatal neutropenia due to anti‐NA 1 antibodies.