Interleukin 1 beta (IL-1β)-dependent inflammatory disorders, such as rheumatoid arthritis and psoriasis, pose a serious medical burden worldwide, where patients face a lifetime of illness and treatment. Organogold compounds have been used since the 1930s to treat rheumatic and other IL-1β-dependent diseases and, though their mechanisms of action are still unclear, there is evidence that gold interferes with the transmission of inflammatory signalling. Here we show for the first time that citrate-stabilized gold nanoparticles, in a size dependent manner, specifically downregulate cellular responses induced by IL-1β both in vitro and in vivo. Our results indicate that the anti-inflammatory activity of gold nanoparticles is associated with an extracellular interaction with IL-1β, thus opening potentially novel options for further therapeutic applications.
We study quasiparticle energy relaxation at subkelvin temperatures by injecting hot electrons into an Al island and measuring the energy flux from quasiparticles into phonons both in the superconducting and in the normal state. The data show strong reduction of the flux at low temperatures in the superconducting state, in qualitative agreement with the theory for clean superconductors. However, quantitatively the energy flux exceeds the theoretical predictions both in the superconducting and in the normal state, suggesting an enhanced or additional relaxation process.
We report inelastic light scattering measurements of spin and charge excitations in nanofabricated AlGaAs/GaAs quantum dots with few electrons. A narrow spin excitation peak is observed and assigned to the intershell triplet-to-singlet monopole mode of dots with four electrons. Configuration-interaction theory provides precise quantitative interpretations that uncover large correlation effects that are comparable to exchange Coulomb interactions.
Correlation among particles in finite quantum systems leads to complex
behaviour and novel states of matter. One remarkable example is predicted to
occur in a semiconductor quantum dot (QD) where at vanishing density the
Coulomb correlation among electrons rigidly fixes their relative position as
that of the nuclei in a molecule. In this limit, the neutral few-body
excitations are roto-vibrations, which have either rigid-rotor or
relative-motion character. In the weak-correlation regime, on the contrary, the
Coriolis force mixes rotational and vibrational motions. Here we report
evidence of roto-vibrational modes of an electron molecular state at densities
for which electron localization is not yet fully achieved. We probe these
collective modes by inelastic light scattering in QDs containing four
electrons. Spectra of low-lying excitations associated to changes of the
relative-motion wave function -the analogues of the vibration modes of a
conventional molecule- do not depend on the rotational state represented by the
total angular momentum. Theoretical simulations via the
configuration-interaction (CI) method are in agreement with the observed
roto-vibrational modes and indicate that such molecular excitations develop at
the onset of short-range correlation.Comment: PDF file only; 24 pages, 7 figures, 2 table. Supplementary
Information include
The aim of the present study was to investigate the effect of silver nanoparticles (AgNP) of different sizes toward two primary producer aquatic species. Thalassiosira pseudonana and Synechococcus sp. have been selected as representative models for the lower trophic organisms in marine and freshwater habitats, respectively. Time-dependent cellular growth was measured upon exposure to both AgNP and silver nitrate (AgNO(3)). In addition, AgNP behavior in freshwater and marine waters has been followed by CPS disc centrifuge, in the time frame of AgNP exposure studies, and the kinetic release of silver from AgNP of different sizes was measured by dialysis and inductively coupled plasma mass spectrometry (ICP-MS). The combination and interpretation of all these data suggest that a shared effect of AgNP and released silver was responsible for the toxicity in both organisms. Furthermore, the toxic effects induced by AgNP exposure in the present study seem to result from a mixture of parameters including aggregated state, size of the AgNP, stability of the preparation, and speciation of the released silver.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.