The somatic comorbidities in unipolar depression are a potential risk not only for the unfavorable course, but also increase the social and economic burden of this disorder. A study conducted on a group of 5054 patients with depressive disorders that were hospitalized in the Neuropsychiatric Hospital of Craiova over a period of 5 years has shown a relatively high frequency of cardiovascular diseases and hyperglycemia, especially in women. The unfavorable course of the mental disorder was significantly associated with a higher frequency of somatic comorbidities, more hospitalizations and a longer duration of hospitalization. These results demonstrate the importance of the multidisciplinary approach for any comorbid association between mental and somatic disorders to improve the outcome of the medical treatment and to ensure a good recovery of the depressive episode.
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