No abstract

In cerebral arteries, alterations of vascular reactivity have been observed but not well molecularly characterized. Therefore, we have hypothesized that cerebrovascular reactivity could be modified by aging via a modification of Ca These results show that aging induces a decrease of contractility correlated with modifications of the expression of genes encoding Ca 2+ signaling toolkit. Globally, the amplitude of Ca 2+ signals was decreased, whereas their duration was increased by a defection of Ca 2+ store refilling.