The increasing incidence rate of thyroid cancer warrants investigation of potentially modifiable factors, especially overweightness. Few prospective studies have investigated anthropometry from childhood to adulthood in relation to thyroid cancer. We analyzed data from 91,909 women of the E3N study, a cohort of French women insured by a national health scheme mostly covering teachers with the age of 40-65 years at inclusion in 1990. Risk estimates of first primary differentiated thyroid cancer (n 5 317) were computed using Cox proportional hazards models. There was a significant doseeffect relationship between thyroid cancer risk and weight or body mass index (BMI) but not height. Compared with women whose BMI was 18.5-22 kg/m 2 , women with BMI 22-25 and those with BMI over 30 had a 39% [95% confidence interval (CI) 7-81] and 76% (12-176) higher risk of thyroid cancer, respectively, with a 21% (5-39) increased risk per 5 kg/m 2 increase in BMI. A large body shape from age 35-40 was significantly associated with an increased risk of differentiated thyroid cancer when compared with a lean one, while earlier body shapes were not. The highest risk was observed in women whose body shape increased from lean to large between menarche and adulthood, with a HR of 2.17 (95% CI 1.04-4.53) when compared with women who were lean at both periods. Our study adds to the existing evidence in relation to excess weight to the risk of thyroid cancer, particularly in women whose body shape increased from menarche to adult age.Incidence of differentiated thyroid cancer has increased over the recent decades, raising concerns about a potential influence of the Chernobyl accident. Evidence points to the rising number of surgeries of nodules as the main reason for such an increase. 1 However, environmental factors are also suspected to play a role, as suggested by a large variation in incidence worldwide. 1 Anthropometry is a good candidate as a potential and modifiable risk factor. A meta-analysis of case-control studies concluded that there exists a significant association between weight and height and risk of thyroid cancer but with significant heterogeneity between studies. 2 From 1 pooled analysis of 12 case-control studies and 1 cohort study, the WCRF report concluded to a potential association between thyroid cancer and body size, possibly through changes in iodine requirement. 3 Few prospective studies have investigated the association between anthropometric measurements and risk of differentiated thyroid cancer, and they provided conflicting results. 4,5 A recent metaanalysis of prospective datasets reported sex-specific relative risks, and it estimated from 3 studies a 14% increased risk per 5 kg/m 2 increase in body mass index (BMI) in women. 6 Observed associations between thyroid cancer and height suggest the influence of growth factors or hormones during childhood or adolescence. 3,7 However, there is little data regarding anthropometry during childhood and adolescence and risk of thyroid cancer.Using the data from the Fre...
The evolution of HT initiation was similar in these two French cohorts, with a substantial drop in HT initiation rate accompanied by changes in the types of HT used.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.