An efficient and reliable electrochemical generator of hypervalent iodine reagents has been developed. In the anodic oxidation of iodoarenes to hypervalent iodine reagents under flowconditions,the use of electricity replaces hazardous and costly chemical oxidants.U nstable hypervalent iodine reagents can be prepared easily and coupled with different substrates to achieve oxidative transformations in high yields. The unstable,e lectrochemically generated reagents can also easily be transformed into classic bench-stable hypervalent iodine reagents through ligand exchange.T he combination of electrochemical and flow-chemistry advantages largely improves the ecological footprint of the overall process compared to conventional approaches.
Es wurdee in effizienter und zuverlässiger elektrochemischer Generator fürh ypervalente Iodreagenzien entwickelt. Bei der anodischen Oxidation von Iodaromaten zu hypervalenten Iodreagenzien unter Flussbedingungen ersetzt der Einsatz von Elektrizitätg efährliche und teure chemische Oxidationsmittel. Instabile hypervalente Iodreagenzien kçnnen leichthergestellt und mit verschiedenen Substraten zur Reaktion gebrachtwerden, um oxidative Funktionalisierungen mit hohen Ausbeuten zu erreichen. Die instabilen elektrochemische rzeugten Reagenzien kçnnen auchl eichtd urch Ligandenaustauschi nk lassische, stabile hypervalente Iodreagenzien umgewandelt werden. Die Kombination aus elektrochemischen und Flow-chemischen Vorteilen verbessert die çko-logischeBilanz des Prozesses im Vergleichzuherkçmmlichen Ansätzen erheblich.
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