Objectives: FN can be a serious complication of CHT, increasing mortality risk and health care costs. Incidence and inpatient hospital costs of FN in Switzerland are currently not reported; therefore this study aimed to: 1. Estimate the number of FN-related hospitalizations. 2. Assess inpatient hospital costs per FN event in Switzerland. MethOds: The main data source was MedStat, a comprehensive database of all Swiss hospitalizations from 1997-2010. BC and NHL cases were identified from ICD-10-GM codes. Hospitalizations for FN were identified by a simultaneous code of BC or NHL and neutropenia. Incident cases of cancer were identified as patients treated in 2010 for the first time since 2002. Results were compared to data from the Foundation National Institute for Cancer Epidemiology and Registration (NICER). Cost data stems from the cantonal hospital of Winterthur. Results: Using MedStat data, 645 male and 557 female NHL patients and 6'391 female BC patients were hospitalized in 2010 for the first time. Corresponding annual incidence data from NICER were 780 male and 688 female NHL patients and 5'388 female BC patients. The proportion of hospitalizations due to FN was 8.2% (190/2'311) among male and 6.0% (123/2'063) among female NHL patients, and was 2.6% (255/9'650) among female BC patients. In-hospital mortality of FN cases was 9.5% for men and 5.7% for women with NHL, and 4.3% for BC. Median inpatient treatment costs for an FN event were CHF 8'399 (mean: CHF 14'006) in NHL and CHF 4'208 (mean: CHF 10'020) in BC. Nursing time was the most important cost component and length of stay was the most important driver of total inpatient cost. cOnclusiOns: 3% to 8% of all hospitalizations in NHL and BC patients were due to FN. Our results suggest that FN leads to considerable risk of death and incurs high in-hospital care cost in Switzerland.
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