Background: GlgE is a maltosyltransferase involved in bacterial ␣-glucan biosynthesis and is a genetically validated antituberculosis target. Results: We have determined the catalytic properties of Streptomyces coelicolor GlgE and solved its structure.
Conclusion:The enzyme has the same catalytic properties as Mycobacterium tuberculosis GlgE and the structure reveals how GlgE functions. Significance: The structure will help guide the development of inhibitors with therapeutic potential.
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