Celia J. Bruton scite author profile

Background: GlgE is a maltosyltransferase involved in bacterial ␣-glucan biosynthesis and is a genetically validated antituberculosis target. Results: We have determined the catalytic properties of Streptomyces coelicolor GlgE and solved its structure. Conclusion:The enzyme has the same catalytic properties as Mycobacterium tuberculosis GlgE and the structure reveals how GlgE functions. Significance: The structure will help guide the development of inhibitors with therapeutic potential.

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The developmental fate of S. coelicolor hyphae depends upon a gene product homologous with the motility σ factor of B. subtilis

Chater

Bruton

Plaskitt

et al. 1989

Cell

175

145

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Celia J. Bruton

λ Red-Mediated Genetic Manipulation of Antibiotic-Producing Streptomyces

Structure of Streptomyces Maltosyltransferase GlgE, a Homologue of a Genetically Validated Anti-tuberculosis Target

The developmental fate of S. coelicolor hyphae depends upon a gene product homologous with the motility σ factor of B. subtilis

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