Cerebral palsy (CP) is the most common motor functional disability in childhood 1,2. Studies have reported that pain is one of the most frequent problems among children with CP, and lack of acknowledgement as well as a lack of acting on the pain negatively affects their quality of life 3-6. In regard to this, pain will, as the limiting factor for children with CP, affect their quality of life by being incapable or unable to participate in physical leisure activities such as soccer, swimming, gymnastics and other social contexts. Moreover, the pain in children with CP can vary considerably both in intensity and bodily location, depending on the gross motor functioning 7. Children with more severe gross motor impairments, Gross Motor Functioning Classification System (GMFCS) levels IV-V, often depend on adult assistance, walking aids or wheelchairs 8 , thus contributing to a limited opportunity for participation 9 .

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Aims: We provide an overview of nationwide environmental data available for Denmark and its linkage potentials to individual-level records with the aim of promoting research on the potential impact of the local surrounding environment on human health. Background: Researchers in Denmark have unique opportunities for conducting large population-based studies treating the entire Danish population as one big, open and dynamic cohort based on nationally complete population and health registries. So far, most research in this area has utilised individual- and family-level information to study the clustering of disease in families, comorbidities, risk of, and prognosis after, disease onset, and social gradients in disease risk. Linking environmental data in time and space to individuals enables novel possibilities for studying the health effects of the social, built and physical environment. Methods: We describe the possible linkage between individuals and their local surrounding environment to establish the exposome – that is, the total environmental exposure of an individual over their life course. Conclusions: The currently available nationwide longitudinal environmental data in Denmark constitutes a valuable and globally rare asset that can help explore the impact of the exposome on human health.

Background: Paracetamol (acetaminophen) is a frequently used nonprescription analgesic with suggested endocrine-disrupting properties. Epidemiological evidence on the effect of paracetamol on male fecundity is sparse. Objectives:To investigate if the use of paracetamol as an oral nonprescription mild analgesic was associated with semen quality in young men. Materials and methods: This cross-sectional study was based on data from the Fetal Programming of Semen Quality (FEPOS; 2017-2019) cohort of 1058 young men (18-21 years) included in the Danish National Birth Cohort. Participants completed a comprehensive online questionnaire on health behavior including analgesic use and provided a semen sample. Negative binomial regression models were used to estimate the percentage differences (adjusted mean ratios [aMR]) in semen quality characteristics according to paracetamol use (no; yes) and frequency of use (almost never; <1/month; ≥1/month; ≥1/week).Results: In total, 28% of the 913 participants with available data reported the use of paracetamol within the last 6 months. We found a slightly higher total sperm count (aMR 1.13 95% CI [0.99-1.30]) in users compared to nonusers but other semen characteristics were unaffected. The frequency of use was suggestive of lower total sperm count and morphologically normal sperm cells primarily among users ≥1/week, however, CIs were wide.Discussion: We were unable to account for the underlying reason for paracetamol use, which may induce confounding by indication. Exposure misclassification due to recall is likely but probably nondifferential due to the participants' young age and unawareness of semen quality. Due to the rapid plasma half-life of paracetamol and few frequent users, it was not possible to conclude on potential high-dose effects.