Background: CD47 and its receptor SIRP␣ are suggested to regulate bone metabolism. Results: Lack of CD47 prevents stromal cell SIRP␣ signaling, which impairs bone marrow stromal cell differentiation, subsequent osteoclast differentiation, and bone homeostasis. Conclusion: CD47 and SIRP␣ both mediate normal bone cell and bone tissue formation. Significance: CD47/SIRP␣ may be a future molecular target to modulate bone homeostasis.
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