No abstract

Primary ovarian insufficiency is a cause of infertility that affects about 1% of women under 40 years old, and is considered as idiopathic in 75% of cases. This review aims to carry out a critical synthesis of the knowledge of the chemical agents likely to affect follicular stock in humans and / or animals, by direct toxicity to follicles, or by increasing their recruitments. For the majority of toxic agents, only experimental data are currently available. We propose a strategy to encourage progress in identifying occupational factors responsible for premature ovarian failure.

Celiac disease is a chronic autoimmune disease, diagnosed in all age groups, associated with intestinal malabsorption and increasingly frequent extra-intestinal manifestations. Its clinical diagnosis depends on the close clinical, laboratory, and morphological correlation. The clinical suspicion leads to highly sensitive and specific serologic tests; however, the intestinal biopsy remains as a reference test, guided by endoscopy, which reveals villous atrophy in the intestinal mucosa.