Blue light (400-500 nm) takes part of the visible electromagnetic spectrum. Natural sunlight blue wavelengths, which are always mixed with green, yellow, and red wavelengths, have been shown to play an important role in the regulation of sleeping patterns and circadian rhythms. 1 However, since the 1980s the development of lightemitting diodes (LED) without red and near-infrared wavelengths and the concomitant exponential use of digital technologies, such as flat-screen TVs, computers, tablets, and smartphones, have led to a drastic increase in human exposure to blue light 2 and to several concerns about their possible involvement in the development of degenerative eye diseases. Moreover, the expansion of therapeutic protocols using blue light irradiation in several dental treatments and dermatologic therapies has highlighted their potential side effects. 3 The toxic and genotoxic effects of blue wavelengths have mainly been studied in the context of their therapeutic and ocular risks: They have been shown to induce cellular dysfunction and
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