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Primary immunodeficiency disease (PID) comprises a genetically heterogeneous group of disorders caused by defects in components of the immune system. PIDs affect different components of the innate and adaptive immune systems, including neutrophils, macrophages, dendritic cells, complement proteins, natural killer (NK) cells, and T-and B-lymphocytes. [1 2] This open-access article is distributed under Creative Commons licence CC-BY-NC 4.0.

The guideline is not context-specific and serves as a universal tool to facilitate clinical decision-making based on best practice evidence. (4,11) The guideline uses a riskstratification approach with a clinical algorithm, including a combination of developmental surveillance, screening and evaluation aimed at the early identification of developmental delays. (1,2,4,10) By extension, the successful implementation of the guideline also results in the appropriate referral of children with developmental delays to intervention therapies, including physiotherapy, occupational therapy and speech therapy, as well as for psychological and educational support-to optimise their developmental outcome. (1,12-14

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