The death of a child is a traumatic event that can have long-term effects on the lives of parents. This study examined bereaved parents of deceased children (infancy to age 34) and comparison parents with similar backgrounds (n = 428 per group) identified in the Wisconsin Longitudinal Study. An average of 18.05 years following the death, when parents were age 53, bereaved parents reported more depressive symptoms, poorer well-being, and more health problems and were more likely to have experienced a depressive episode and marital disruption than were comparison parents. Recovery from grief was associated with having a sense of life purpose and having additional children but was unrelated to the cause of death or the amount of time since the death. The results point to the need for detection and intervention to help those parents who are experiencing lasting grief. Keywords bereavement; nonnormative parenting; death of child; parental grief; midlife Each year, over 50,000 U.S. children die (U.S. National Center for Health Statistics, 2000). The death of a child is one of the most painful events that an adult can experience and is linked to complicated/traumatic grief reactions (Prigerson et al., 1999). For parents, the dissolution of the attachment relationship with the child elicits severe anxiety and other negative emotions associated with loss (Bowlby, 1980). Parents might also experience guilt about having been unable to protect the child (Gilbert, 1997). Furthermore, because the death of a child defies the expected order of life events, many parents experience the event as a challenge to basic existential assumptions (Wheeler, 2001).In light of the significance of child death as a traumatic experience for parents, research on parental bereavement is more limited than might be expected. Most studies have been clinical NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript descriptions of participants in grief support groups (e.g., Compassionate Friends), so the findings likely have been influenced both by the self-selection factors that led individuals to seek this type of help and by the participants' experiences in the support groups. As a result, the findings cannot be generalized to the broader population of bereaved parents. Furthermore, drawing from traditional models of grief resolution that emphasize relatively short-term adaptations, researchers have usually assessed functioning for only a brief period during the acute phase of bereavement. Few studies have examined longer term outcomes, and most that have done so have used retrospective reports, which are subject to distortion when individuals recall their functioning many years earlier (e.g., Nelson & Frantz, 1996;Stehbens & Lascari, 1974).The purpose of the present study was to examine the life course impacts of parental bereavement in an unselected sample of adults who were studied prospectively from early adulthood, prior to the birth of the child, to middle age, usually many years after the death of the child. We ide...

RIPK2 mediates inflammatory signaling by the bacteria‐sensing receptors NOD1 and NOD2. Kinase inhibitors targeting RIPK2 are a proposed strategy to ameliorate NOD‐mediated pathologies. Here, we reveal that RIPK2 kinase activity is dispensable for NOD2 inflammatory signaling and show that RIPK2 inhibitors function instead by antagonizing XIAP‐binding and XIAP‐mediated ubiquitination of RIPK2. We map the XIAP binding site on RIPK2 to the loop between β2 and β3 of the N‐lobe of the kinase, which is in close proximity to the ATP‐binding pocket. Through characterization of a new series of ATP pocket‐binding RIPK2 inhibitors, we identify the molecular features that determine their inhibition of both the RIPK2‐XIAP interaction, and of cellular and in vivo NOD2 signaling. Our study exemplifies how targeting of the ATP‐binding pocket in RIPK2 can be exploited to interfere with the RIPK2‐XIAP interaction for modulation of NOD signaling.

Qualitative and quantitative Block Design performance was examined in Vietnam combat veterans with PTSD diagnoses (n = 23) and Vietnam combat veterans without PTSD or other mental disorders diagnoses (n = 19). Results indicated that PTSD-diagnosed veterans committed more single block rotations than the comparison sample, and that their errors occurred more frequently in right hemispace than errors made by the comparison sample. The two groups did not differ in the number of configural errors made, errors committed in left hemispace, or in quantitative performance measures. Findings are suggestive of relative left hemisphere hypoactivation and are congruent with prior research documenting cerebral asymmetries in emotional disorders.

We investigated narcissism as a moderator of social loafing on a physical performance task. High and low narcissistic individuals twice performed a cycling task in same-sex teams of three: once when identifiability was low; and once when identifiability was high. A significant interaction between narcissism and identifiability was revealed, F(1, 40) = 4.09, p < .05, eta2 = .09 for performance. Follow-up tests indicated that high narcissists' performance significantly increased with greater identifiability, whereas low narcissists displayed no such performance differences. Results suggested that this effect was due to an increase in narcissists' on-task effort (ratings of perceived exertion and heart rate) when they knew that their performance was to be identified.

Compared with GW controls, GW cases meeting criteria for GWI had preserved cognition function but had significant psychiatric symptoms and lower quality of life.

In patients with multiple sclerosis (MS), attention and information-processing-speed impairment contribute to dysfunction in other cognitive domains (learning, memory). Treatment for MS-related attention and processing-speed deficits may have dual benefits: improvement of function in these domains and in overall cognitive efficiency. The objective of this study was to determine whether adjunctive treatment of fatigue with modafinil ameliorates deficits in attention and cognitive domains reliant on attention. Relapsing-remitting MS patients receiving intramuscular interferon beta-1a (IM IFNβ-1a) were screened for attention problems with four well-validated, reliable, standardized neurocognitive measures sensitive to attention impairment. Those scoring at least 1 standard deviation below normative expectations on at least two of the measures were eligible for continued participation. Participants with normal values on all physical screening measures were randomized to one of two groups: continued IM IFNβ-1a alone or plus modafinil. Significant mean group differences were found at 4 months on multiple measures of fatigue and cognitive functioning. Patients on combination therapy reported significantly less fatigue (P &lt;.05) and performed significantly better (P &lt;.05) than those in the monotherapy group on measures tapping simple attention span, working memory, and phonemic verbal fluency. Combination therapy was generally well tolerated. No serious adverse events were reported by patients in either treatment arm. This study was developed as a proof of concept that attention-enhancing medications could be used to address fatigue, cognition, and mood in MS patients. The results demonstrate the need for a larger study to determine relative safety and efficacy.

A magnetotail‐like structure is modelled using a 2‐dimensional, single‐ion species, electromagnetic, Darwin (no displacement current), particle‐in‐cell (PIC) code, which is a modified version of that described by Hamilton and Eastwood [1982]. The modifications include new boundary conditions for the magnetic fields which allow a non‐symmetrical topology to be modelled. The work presented here is aimed at the construction and testing of a self‐consistent ‘steady‐state’ model. It is found that the model supports significant magnetic perturbations, arising as a consequence of cyclotron resonance interactions with ion beam‐like features. When subjected to transient changes in the convection electric field, the model also exhibits field reconfiguration and particle responses reminiscent of near‐Earth substorm behaviour.