Several parent and child factors were consistently linked with functional disability, whereas better family functioning was associated with functional ability. Applying an ecological framework, assisted identification of areas for further research, and provides direction for treatments that may be more effective in optimizing long-term functional outcomes, extending current psychological approaches.

Objectives: Sensory modulation patterns contribute to altered pain perception and disengagement in activities; atypical sensory modulation patterns have been associated with higher pain sensitivity, catastrophizing, and reduced function.Objectives of this study were to ascertain whether: adolescents with persistent pain had atypical sensory modulation patterns, atypical sensory modulation was associated with reduced functioning and higher pain, and pain catastrophizing mediated the relationship between sensory modulation and functional disability. Methods: Adolescents (N = 70, Females = 63, Males = 7) attending tertiary level interdisciplinary team assessment for persistent pain completed sensory modulation (Adolescent/Adult Sensory Profile), pain catastrophizing (Bath Adolescent Pain Questionnaire), pain intensity, functional disability (Functional Disability Index), and quality of life (Pediatric Quality of Life (QOL) Scales) questionnaires.Results: Adolescents with persistent pain had atypical patterns of sensory modulation compared to normative data. Sensory modulation patterns were not associated with pain intensity; however, higher sensitivity was associated with greater disability (r = .36, p < .01), and lower registration of sensation was associated with poorer emotional (r = .31, p < .01), social (r = .35, p < .01), and school-related (r = .49, p < .001) QOL.Sensory modulation, pain intensity, and catastrophizing contributed independently to disability; catastrophizing mediated sensory sensitivity and both functional disability and emotional QOL. Discussion:This study is the first to demonstrate that atypical sensory modulation patterns are associated with poorer function for adolescents with persistent pain, suggesting that individualized sensory-informed interventions can potentially facilitate participation in daily activities and improve QOL.