BackgroundIron metabolism disorders have been associated with an increased risk of
cardiovascular events. However, the prognostic impact on patients (pts) with
acute coronary syndrome (ACS) has yet to be clarified.ObjectiveTo determine the prognostic value of serum iron and ferritin levels in pts
with ACS in the short and long-term.MethodsConsecutive pts admitted to a coronary care unit with a diagnosis of ACS, for
a period of 2 years, were evaluated. The population was divided into
tertiles of serum iron and ferritin distribution. The primary adverse events
were the occurrence of in-hospital death or heart failure (HF) and death or
HF at 1 year of follow-up.ResultsWe studied 280 pts (73% males; mean age 68 ± 13 years). The mean
levels of serum iron and ferritin were 59 ± 34 mcg/dL and 205
± 185 ng/mL, respectively. Patients included in the 1st
tertile of serum iron (≤ 40 mcg/dL) had a higher rate of adverse
events, in-hospital and after 1 year. Lower and higher levels of ferritin
(1st and 3rd tertiles, ≤ 110; >219
ng/ml, respectively) were associated with a higher incidence of HF during
hospitalization and death at 1 year. A ferritin value >316 ng /mL was an
independent risk factor for death at 1 year (adjusted OR: 14; 95%CI: 2.6 to
75.9).ConclusionIn this population, iron metabolism alterations were associated with a higher
rate of adverse events and higher ferritin levels constituted an independent
mortality predictor in the long-term.
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