The prevalence of MRSA in children with AD is clearly on the rise. This has negative consequences for individuals with AD and is also a major public health problem.
for administrations during CytoSorb w use than for the adjacent peak levels. Finally, the meropenem peak level during the second period of CytoSorb w use was substantially lower than the peak level before use. The observed substantially lower linezolid peak levels during CytoSorb w use might be due to adsorption by the cytokine filter. Indeed, different endogenous substances, apart from cytokines, are reported to be adsorbed by cytokine filters. 6 Adsorption would also explain the lower peak level of meropenem during the second use of CytoSorb w. However, blood samples were not collected at optimal timepoints for meropenem; hence, the information for this antibiotic is limited. It should be mentioned that the high intra-individual variability observed for both antibiotics might also be due to the effects of critical illness. 4,7 However, because of the possible adsorption of antibiotics by cytokine filters, therapeutic drug monitoring (TDM) might be especially important for patients using such systems. Indeed, first guidelines already recommended the use of TDM in critically ill patients. 8,9 If TDM is not available, high loading doses or shorter intervals between antibiotic administrations could be used to achieve adequate antibiotic levels. The results suggest that further studies are needed to understand the impact of cytokine filters on the concentrations of different antimicrobials.
This study demonstrates that DLQI and PASI remain low after 12 months, and, in fact, both gradually decline further with time. Patients on biologic agents for prolonged periods maintained their improvement in QoL for up to 6.5 years.
We report two cases of adults with urticarial dermatitis who could not be managed by a variety of treatments but who obtained good control with mycophenolate mofetil (MMF). A clinical response was seen 6-8 weeks from treatment onset and they were maintained on MMF 1 g twice daily (case 1), and MMF 1 g omni mane and 500 mg omni nocte (case 2), with no major exacerbations for many years. MMF is an immunosuppressive agent, which is currently used off-label for many dermatological conditions. To date, there have been no studies investigating the use of MMF as a treatment for urticarial dermatitis. The cases we present suggest that MMF is an effective treatment for this condition, and we recommend that MMF be considered as a treatment option.
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