here is increasing evidence that SARS-CoV-2 not only affects the respiratory tract but also impacts the CNS, resulting in neurological symptoms such as loss of smell and taste, headache , fatigue, nausea and vomiting in more than one-third of individuals with COVID-19 (refs. 1,2). Moreover, acute cerebrovascular disease and impaired consciousness have been reported 3. While Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19

39The newly identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes 40 COVID-19, a pandemic respiratory disease presenting with fever, cough, and often pneumonia. 41Moreover, thromboembolic events throughout the body including the central nervous system (CNS) 42