The use of hydrazones as a new type of submonomer in peptoid synthesis is described, giving access to peptoid monomers that are structure-inducing. A wide range of hydrazones were found...
The
synthesis of peptoids possessing multiple cis-inducing
monomers with alkylammonium side chains is reported, where
chloropropyl side chains are diversified on a solid support by late-stage
SN2 displacements with amines. The conditions were optimized
for a wide variety of primary, secondary, and tertiary alkyl amine
nucleophiles. We also demonstrated that multiple chloride displacements
could be achieved on sequences possessing trans-inducing N-aryl- and N-imino glycine monomers.
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