Exercise is impaired in hot, compared with moderate, conditions. The development of hyperthermia is strongly linked to the impairment and as a result various strategies have been investigated to combat this condition. This meta-analysis focused on the most popular strategy: cooling. Precooling has received the most attention but recently cooling applied during the bout of exercise has been investigated and both were reviewed. We conducted a literature search and retrieved 28 articles which investigated the effect of cooling administered either prior to (n=23) or during (n=5) an exercise test in hot (wet bulb globe temperature >26°C) conditions. Mean and weighted effect size (Cohen's d) were calculated. Overall, precooling has a moderate (d=0.73) effect on subsequent performance but the magnitude of the effect is dependent on the nature of the test. Sprint performance is impaired (d=−0.26) but intermittent performance and prolonged exercise are both improved following cooling (d=0.47 and d=1.91, respectively). Cooling during exercise has a positive effect on performance and capacity (d=0.76). Improvements were observed in studies with and without cooling-induced physiological alterations, and the literature supports the suggestion of a dose–response relationship among cooling, thermal strain and improvements in performance and capacity. In summary, precooling can improve subsequent intermittent and prolonged exercise performance and capacity in a hot environment but sprint performance is impaired. Cooling during exercise also has a positive effect on exercise performance and capacity in a hot environment.

This study represents the first time that muscle damage, endocrine, and immune markers have been measured, together with activity profile, during a competitive soccer match. Seven semiprofessional soccer players participated in a competitive league match. Blood and saliva samples were obtained 1 hour before kick off and immediately postmatch. Global positioning system equipment was used to measure heart rate and activity profile data throughout the match. Percentage increase in creatine kinase (CK) and myoglobin (MYO) concentrations was correlated with the number of sprints performed during the match (r = 0.88, p = 0.019; r = 0.75, p = 0.047, respectively). Creatine kinase increased by 84% (p = 0.17) from prematch to postmatch, whereas MYO increased by 238% (p = 0.05). Players performed 39 ± 18 sprints during the course of the match. Cortisol increased by 78% (p = 0.103), whereas testosterone increased significantly by 44% (p = 0.004). No differences were seen from prematch to postmatch in the testosterone to cortisol ratio, immunoglobulin (Ig) A, IgM, or IgG. Sprinting is correlated with changes in CK and MYO and may therefore be associated with muscle damage in semiprofessional soccer players.

Results show that BA improved high-intensity cycling capacity. However, despite a 6-s (∼4%) increase in TTE with the addition of SB, this did not reach statistical significance, but magnitude-based inferences suggested a ∼70% probability of a meaningful positive difference.

Results: In the post-acclimation trial distance run was increased by 33% in the acclimation group (A: 7703 ± 1401 vs B: 10215 ± 1746m; interaction group x trial P<0.05), but was unchanged in the moderate and control groups. The acclimation group had a lower rectal temperature (interaction group x trial x time P<0.01) due to a lower rate of rise, and an increase in thermal comfort [1] after acclimation (End A: 7 ± 2 vs 6 ± 2; interaction group x trial P<0.01). There was no difference in serum

The aim of this two-part experiment was to investigate the effect of cooling the neck on time-trial performance in hot conditions (~30°C; 50% RH). In Study A, nine participants completed a 75-min submaximal (~60% V(O₂(max)) pre-load phase followed by a 15-min self-paced time-trial (TT) on three occasions: one with a cooling collar (CC(90)), one without a collar (NC(90)) and one with the collar uncooled (C(90)). In Study B, eight participants completed a 15-min TT twice: once with (CC(15)) and once without (NC(15)) a cooling collar. Time-trial performance was significantly improved in Study A in CC(90) (3,030 ± 485 m) compared to C(90) (2,741 ± 537 m; P = 0.008) and NC(90) (2,884 ± 571 m; P = 0.041). Fifteen-minute TT performance was unaffected by the collar in Study B (CC(15) = 3,239 ± 267 m; NC(15) = 3,180 ± 271 m; P = 0.351). The collar had no effect on rectal temperature, heart rate or RPE. There was no effect of cooling the neck on S100β, cortisol, prolactin, adrenaline, noradrenaline or dopamine concentrations in Study A. Cooling the neck via a cooling collar can improve exercise performance in a hot environment but it appears that there may be a thermal strain threshold which must be breached to gain a performance benefit from the collar.

Context: Cooling the neck region can improve the ability to exercise in a hot environment. It might improve performance by dampening the perceived level of thermal strain, allowing individuals to override inhibitory signals.Objective: To investigate whether the enhanced ability to exercise in a hot environment observed when cooling the neck region occurs because of dampening the perceived level of thermal strain experienced and the subsequent overriding of inhibitory signals.Design: Crossover study. Setting: Walk-in environmental chamber.Patients or Other Participants: Eight endurance-trained, nonacclimated men (age 5 26 6 2 years, height 5 1.79 6 0.04 m, mass 5 77.0 6 6.2 kg, maximal oxygen uptake [V O 2max ] 5 56.2 6 9.2 mL?kg 21 ?min 21 ) participated.Intervention(s): Participants completed 4 running tests at approximately 70% V O 2max to volitional exhaustion: 2 familiarization trials followed by 2 experimental trials (cooling collar [CC] and no collar [NC]). Trials were separated by 7 days. Familiarization and NC trials were performed without a collar and used to assess the test variability.Main Outcome Measure(s): Time to volitional exhaustion, heart rate, rectal temperature, neck skin temperature, rating of perceived exertion, thermal sensation, and feeling scale (pleasure/displeasure) were measured.Results: Time to volitional exhaustion was increased by 13.5% 6 3.8% (CC 5 43.15 6 12.82 minutes, NC 5 38.20 6 11.70 minutes; t 7 5 9.923, P , .001) with the CC, which reduced mean neck skin temperature throughout the test (P , .001). Participants terminated exercise at identical levels of perceived exertion, thermal sensation, and feeling scale, but the CC enabled participants to tolerate higher rectal temperatures (CC 5 39.616C 6 0.456C, NC 5 39.186C 6 0.76C; t 7 5 23.217, P 5 .02) and heart rates (CC 5 181 6 6 beats/min, NC 5 178 6 9 beats/min; t 7 5 22.664, P 5 .03) at the point of termination.Conclusions: Cooling the neck increased the time taken to reach volitional exhaustion by dampening the perceived levels of thermal strain.Key Words: hyperthermia, thermoregulation, treadmill, exhaustion, fatigue Key Points N Cooling the neck region dampened the perceived level of thermal strain, enabling participants to increase the time to reach volitional exhaustion. N Dampening of the perceived level of thermal strain delayed the point of voluntary termination of exercise. N When their neck regions were cooled, participants tolerated higher rectal temperatures and heart rates before they voluntarily terminated exercise than when their neck regions were not cooled.

The reason for high altitude anorexia is unclear but could involve alterations in the appetite hormones ghrelin and peptide YY (PYY). This study examined the effect of resting and exercising in hypoxia (12.7% O(2); ∼4,000 m) on appetite, energy intake, and plasma concentrations of acylated ghrelin and PYY. Ten healthy males completed four, 7-h trials in an environmental chamber in a random order. The four trials were control-normoxia, control-hypoxia, exercise-normoxia, and exercise-hypoxia. During exercise trials, participants ran for 60 min at 70% of altitude-specific maximal oxygen consumption (Vo(2max)) and then rested. Participants rested throughout control trials. A standardized meal was consumed at 2 h and an ad libitum buffet meal at 5.5 h. Area under the curve values for hunger (assessed using visual analog scales) tended to be lower during hypoxic trials than normoxic trials (repeated-measures ANOVA, P = 0.07). Ad libitum energy intake was lower (P = 0.001) in hypoxia (5,291 ± 2,189 kJ) than normoxia (7,718 ± 2,356 kJ; means ± SD). Mean plasma acylated ghrelin concentrations were lower in hypoxia than normoxia (82 ± 66 vs. 100 ± 69 pg/ml; P = 0.005) while PYY concentrations tended to be higher in normoxia (32 ± 4 vs. 30 ± 3 pmol/l; P = 0.059). Exercise suppressed hunger and acylated ghrelin and increased PYY but did not influence ad libitum energy intake. These findings confirm that hypoxia suppresses hunger and food intake. Further research is required to determine if decreased concentrations of acylated ghrelin orchestrate this suppression.

Tables: 3 2 Abstract Purpose: The aim of this study was to determine whether gastrointestinal (GI) distress affects the ergogenicity of sodium bicarbonate and whether the degree of alkalaemia or other metabolic responses are different between individuals who improve exercise capacity and those who do not. Methods: Twenty-one males completed two cycling capacity tests at 110% of maximum power output. Participants were supplemented with 0.3 g•kg -1 BM of either placebo (maltodextrin) or sodium bicarbonate (SB). Blood pH, bicarbonate, base excess and lactate were determined at baseline, pre-exercise, immediately post-exercise and 5 minutes post-exercise. Results: SB supplementation did not significantly increase total work done (TWD) (P = 0.16, 46.8 ± 9.1 vs. 45.6 ± 8.4 kJ, d = 0.14), although magnitude based inferences suggested a 63% likelihood of a positive effect. When data were analysed without four participants who experienced GI discomfort, TWD (P = 0.01) was significantly improved with SB. Immediately post-exercise blood lactate was higher in SB for the individuals who improved but not for those who didn't. There were also differences in the pre to post-exercise change in blood pH, bicarbonate and base excess between individuals who improved and individuals who did not. Conclusions: SB improved high intensity cycling capacity, but only with the exclusion of participants experiencing GI discomfort. Differences in blood responses suggest that sodium bicarbonate may not be beneficial to all individuals. Magnitude based inferences suggested that the exercise effects are unlikely to be negative; therefore individuals should determine whether they respond well to sodium bicarbonate supplementation prior to competition. Key words: Extracellular buffering, high-intensity exercise, gastrointestinal distress, blood responses, inter-individual variability 3 IntroductionThe effects of sodium bicarbonate supplementation on exercise performance and capacity have been well researched (for review see 1 ), and a recent meta-analysis showed that 0.3 g·kg -1 Body Mass (BM) sodium bicarbonate supplementation prior to a 60 s sprint improved performance by 1.7 ± 2.0% 2 . Despite this, the reported effects are equivocal, with several studies reporting no effect on exercise performance and capacity 3,4,5,6,7 . Inconsistencies in the performance outcomes of sodium bicarbonate supplementation studies can be partly attributed to differing dosing regimens 4 , gastrointestinal (GI) discomfort experienced by some participants 8 , exercise models insufficient to be limited by hydrogen cation (H + ) accumulation 5 and individual variation in the response to supplementation 9 .